Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2986802..2987450 Replicon chromosome
Accession NZ_CP041871
Organism Mycobacterium tuberculosis strain 1-0021P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ35_RS13965 Protein ID WP_003899414.1
Coordinates 2986802..2987125 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ35_RS13970 Protein ID WP_003899415.1
Coordinates 2987205..2987450 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ35_RS13935 2982125..2983123 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ35_RS13940 2983137..2983601 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ35_RS13945 2983589..2983840 + 252 WP_003908028.1 hypothetical protein -
FPJ35_RS13950 2984011..2985450 - 1440 WP_003901443.1 phage major capsid protein -
FPJ35_RS13955 2985458..2985991 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ35_RS13960 2986144..2986635 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ35_RS13965 2986802..2987125 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ35_RS13970 2987205..2987450 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ35_RS13975 2987447..2988873 - 1427 Protein_2756 DUF3631 domain-containing protein -
FPJ35_RS13980 2988875..2989267 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ35_RS13985 2989264..2989524 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ35_RS13990 2989541..2989903 - 363 WP_003900543.1 hypothetical protein -
FPJ35_RS13995 2989906..2991033 - 1128 WP_003899420.1 site-specific integrase -
FPJ35_RS14000 2991178..2991405 - 228 WP_003899421.1 hypothetical protein -
FPJ35_RS14005 2991402..2991791 - 390 WP_003899422.1 hypothetical protein -
FPJ35_RS14010 2991697..2991969 + 273 WP_003900544.1 hypothetical protein -
FPJ35_RS14015 2992068..2992301 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2982125..2991033 8908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(18-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T134301 WP_003899414.1 NZ_CP041871:c2987125-2986802 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T134301 NZ_CP041871:c2987125-2986802 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT134301 WP_003899415.1 NZ_CP041871:c2987450-2987205 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT134301 NZ_CP041871:c2987450-2987205 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References