134182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2970051..2970699 Replicon chromosome
Accession NZ_CP041869
Organism Mycobacterium tuberculosis strain 1-0028P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ37_RS13880 Protein ID WP_003899414.1
Coordinates 2970051..2970374 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ37_RS13885 Protein ID WP_003899415.1
Coordinates 2970454..2970699 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ37_RS13850 2965374..2966372 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ37_RS13855 2966386..2966850 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ37_RS13860 2966838..2967089 + 252 WP_003908028.1 hypothetical protein -
FPJ37_RS13865 2967260..2968699 - 1440 WP_003901443.1 phage major capsid protein -
FPJ37_RS13870 2968707..2969240 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ37_RS13875 2969393..2969884 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ37_RS13880 2970051..2970374 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ37_RS13885 2970454..2970699 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ37_RS13890 2970696..2972123 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ37_RS13895 2972125..2972517 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ37_RS13900 2972514..2972774 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ37_RS13905 2972791..2973153 - 363 WP_003900543.1 hypothetical protein -
FPJ37_RS13910 2973156..2974283 - 1128 WP_003899420.1 site-specific integrase -
FPJ37_RS13915 2974428..2974655 - 228 WP_003899421.1 hypothetical protein -
FPJ37_RS13920 2974652..2975041 - 390 WP_003899422.1 hypothetical protein -
FPJ37_RS13925 2974947..2975219 + 273 WP_003900544.1 hypothetical protein -
FPJ37_RS13930 2975318..2975551 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2965374..2974283 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T134182 WP_003899414.1 NZ_CP041869:c2970374-2970051 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T134182 NZ_CP041869:c2970374-2970051 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT134182 WP_003899415.1 NZ_CP041869:c2970699-2970454 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT134182 NZ_CP041869:c2970699-2970454 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References