Detailed information of TA system TA134115

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2386670..2387365
• Replicon: chromosome
• Accession: NZ_CP041868
• Organism: Mycobacterium tuberculosis strain 1-0030P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ38_RS11015
• Protein ID: WP_014588493.1
• Coordinates: 2386670..2387104 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: FPJ38_RS11020
• Protein ID: WP_003410814.1
• Coordinates: 2387111..2387365 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ38_RS11005	2382824..2385865	+	3042	WP_031684591.1	DEAD/DEAH box helicase	-
FPJ38_RS11010	2385858..2386691	+	834	WP_003899172.1	SWIM zinc finger family protein	-
FPJ38_RS11015	2386670..2387104	-	435	WP_014588493.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ38_RS11020	2387111..2387365	-	255	WP_003410814.1	antitoxin	Antitoxin
FPJ38_RS11025	2387381..2387638	-	258	WP_003410816.1	hypothetical protein	-
FPJ38_RS11030	2388585..2388881	+	297	WP_003410820.1	PE family protein	-
FPJ38_RS11035	2388937..2389668	+	732	WP_003900467.1	PPE family protein	-
FPJ38_RS11040	2390208..2390954	-	747	WP_003901330.1	proteasome subunit alpha	-
FPJ38_RS11045	2390951..2391826	-	876	WP_003411023.1	proteasome subunit beta	-
FPJ38_RS11050	2391823..2392017	-	195	WP_003411026.1	ubiquitin-like protein Pup	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15690.13 Da
• Isoelectric Point: 7.4681

>T134115 WP_014588493.1 NZ_CP041868:c2387104-2386670 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGVDRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T134115 NZ_CP041868:c2387104-2386670 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGTCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT134115 WP_003410814.1 NZ_CP041868:c2387365-2387111 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT134115 NZ_CP041868:c2387365-2387111 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Antitoxin

• AlphaFold DB: G0TMN0