133808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2189583..2190451 Replicon chromosome
Accession NZ_CP041863
Organism Mycobacterium tuberculosis strain 1-0045P6C4

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag FPJ43_RS10125 Protein ID WP_010886136.1
Coordinates 2189583..2189960 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag FPJ43_RS10130 Protein ID WP_003409886.1
Coordinates 2190002..2190451 (+) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ43_RS10075 2185372..2185824 - 453 WP_003899095.1 lipoprotein -
FPJ43_RS10080 2185888..2186289 + 402 WP_003409869.1 hypothetical protein -
FPJ43_RS10085 2186282..2186464 - 183 WP_003409870.1 hypothetical protein -
FPJ43_RS10090 2186578..2186928 - 351 WP_003409871.1 hypothetical protein -
FPJ43_RS10095 2186939..2187841 - 903 WP_003899097.1 hypothetical protein -
FPJ43_RS10100 2187862..2188053 - 192 WP_003409876.1 hypothetical protein -
FPJ43_RS10105 2188054..2188350 - 297 WP_003409877.1 hypothetical protein -
FPJ43_RS10110 2188590..2188805 + 216 WP_003409878.1 antitoxin -
FPJ43_RS10115 2188802..2189113 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ43_RS10120 2189087..2189608 - 522 WP_003904745.1 hypothetical protein -
FPJ43_RS10125 2189583..2189960 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
FPJ43_RS10130 2190002..2190451 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FPJ43_RS10135 2190448..2190993 + 546 WP_003409891.1 SecB-like chaperone -
FPJ43_RS10140 2190882..2191496 - 615 WP_003901296.1 hypothetical protein -
FPJ43_RS10145 2191545..2191841 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPJ43_RS10150 2191838..2192089 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
FPJ43_RS10155 2192076..2192570 + 495 WP_003899099.1 hypothetical protein -
FPJ43_RS10160 2192730..2193137 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ43_RS10165 2193141..2193413 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ43_RS10170 2193446..2194666 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-113)

Antitoxin

(44-91)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T133808 WP_010886136.1 NZ_CP041863:2189583-2189960 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T133808 NZ_CP041863:2189583-2189960 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT133808 WP_003409886.1 NZ_CP041863:2190002-2190451 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT133808 NZ_CP041863:2190002-2190451 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCATCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU


Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References