Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2279124..2280046 Replicon chromosome
Accession NZ_CP041862
Organism Mycobacterium tuberculosis strain 1-0047P6C4

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag FPJ44_RS10615 Protein ID WP_193076246.1
Coordinates 2279438..2280046 (-) Length 203 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag FPJ44_RS10610 Protein ID WP_003410124.1
Coordinates 2279124..2279429 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ44_RS10580 2274135..2275391 - 1257 WP_016720149.1 HNH endonuclease -
FPJ44_RS10585 2275745..2276320 + 576 WP_003410100.1 hypothetical protein -
FPJ44_RS10590 2276317..2277357 + 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
FPJ44_RS10595 2277599..2278318 + 720 WP_003410108.1 DUF433 domain-containing protein -
FPJ44_RS10600 2278308..2278724 + 417 WP_003410114.1 hypothetical protein -
FPJ44_RS10605 2278740..2279039 - 300 WP_003410120.1 hypothetical protein -
FPJ44_RS10610 2279124..2279429 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
FPJ44_RS10615 2279438..2280046 - 609 WP_193076246.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ44_RS10625 2281426..2281785 - 360 WP_003410131.1 hypothetical protein -
FPJ44_RS10630 2281945..2282622 - 678 WP_003900450.1 hypothetical protein -
FPJ44_RS10635 2282574..2282810 - 237 WP_003410133.1 hypothetical protein -
FPJ44_RS10640 2283017..2283913 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(87-182)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 203 a.a.        Molecular weight: 22913.15 Da        Isoelectric Point: 7.6044

>T133754 WP_193076246.1 NZ_CP041862:c2280046-2279438 [Mycobacterium tuberculosis]
IRESPDSPGRFSALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTA
DVERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAA
GNKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 609 bp

>T133754 NZ_CP041862:c2280046-2279438 [Mycobacterium tuberculosis]
ATCAGAGAGTCTCCGGACTCACCGGGGCGGTTCAGCGCACTGTACTGCCTCATACGTGGGGATGAATTCTCGGCCTGGCA
CAGGCTACTGTTTCAACGGCCCGGGTGCGCAGAGTCCGTCCTCGCCTGCCGGCATTTCCTCGACGGTAGCCCCGTCGCCC
GCTGCTCTTACCCGGAGGAATATCACCCTTGTGTGATATCGCGTATCGCGCTACTCTGCGACTCTGTGGGGTGGACGGCG
GATGTGGAGCGCATCTCCGCCTGGCTCAACGGCTTGGACCGAGAGACCTACGAATTGGTGTTCGCAGCTATCGAGGTTCT
CGAGGAAGAGGGCCCCGCACTTGGCTGTCCTCTGGTGGACACGGTGCGTGGGTCGCGCCACAAGAACATGAAGGAGCTGC
GTCCAGGATCACAAGGGCGGTCCGAGGTCCGCATTCTGTTCGCCTTCGACCCGGCGCGGCAGGCGATCATGCTGGCCGCC
GGTAACAAGGCCGGGCGGTGGACCCAGTGGTACGACGAGAAGATCAAAGCGGCCGATGAGATGTTTGCCGAACATCTCGC
ACAGTTCGAGGACACGAAGCCAAAGAGGCGCAAGCGCAAGAAAGGGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT133754 WP_003410124.1 NZ_CP041862:c2279429-2279124 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT133754 NZ_CP041862:c2279429-2279124 [Mycobacterium tuberculosis]
ATGGCGATGACACTACGGGACATGGACGCCGTACGTCCCGTTAACCGGGAGGCGGTGGACCGGCACAAGGCACGAATGCG
CGATGAAGTGCGGGCATTCCGGCTCCGGGAGCTGCGCGCGGCTCAGTCACTCACCCAGGTCCAGGTGGCTGCGCTGGCGC
ACATCCGGCAGAGCCGGGTATCCAGCATCGAGAACGGCGACATCGGCTCCGCACAGGTCAACACACTGCGCAAATACGTG
TCCGCTCTTGGCGGAGAACTGGATATCACCGTCCGCCTGGGAGATGAGACATTCACCCTGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References