Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3735311..3735985 Replicon chromosome
Accession NZ_CP041853
Organism Mycobacterium tuberculosis strain 1-0107P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPJ55_RS17510 Protein ID WP_003417282.1
Coordinates 3735311..3735739 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPJ55_RS17515 Protein ID WP_003417286.1
Coordinates 3735743..3735985 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ55_RS17485 3731133..3731534 - 402 WP_003417264.1 cytidine deaminase -
FPJ55_RS17490 3731675..3732109 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FPJ55_RS17495 3732106..3732540 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPJ55_RS17500 3732669..3734441 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPJ55_RS17505 3734441..3735232 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPJ55_RS17510 3735311..3735739 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ55_RS17515 3735743..3735985 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ55_RS17520 3736107..3736721 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPJ55_RS17525 3736718..3737383 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPJ55_RS17530 3737384..3737917 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPJ55_RS17535 3737914..3738288 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPJ55_RS17540 3738385..3739449 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T133234 WP_003417282.1 NZ_CP041853:c3735739-3735311 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T133234 NZ_CP041853:c3735739-3735311 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT133234 WP_003417286.1 NZ_CP041853:c3735985-3735743 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT133234 NZ_CP041853:c3735985-3735743 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References