Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 3003400..3004048 Replicon chromosome
Accession NZ_CP041853
Organism Mycobacterium tuberculosis strain 1-0107P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ55_RS14030 Protein ID WP_003899414.1
Coordinates 3003400..3003723 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ55_RS14035 Protein ID WP_003899415.1
Coordinates 3003803..3004048 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ55_RS14000 2998723..2999721 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ55_RS14005 2999735..3000199 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ55_RS14010 3000187..3000438 + 252 WP_003908028.1 hypothetical protein -
FPJ55_RS14015 3000609..3002048 - 1440 WP_003901443.1 phage major capsid protein -
FPJ55_RS14020 3002056..3002589 - 534 WP_031689496.1 HK97 family phage prohead protease -
FPJ55_RS14025 3002742..3003233 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ55_RS14030 3003400..3003723 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ55_RS14035 3003803..3004048 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ55_RS14040 3004045..3005472 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ55_RS14045 3005474..3005866 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ55_RS14050 3005863..3006123 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ55_RS14055 3006140..3006502 - 363 WP_003900543.1 hypothetical protein -
FPJ55_RS14060 3006505..3007632 - 1128 WP_003899420.1 site-specific integrase -
FPJ55_RS14065 3007777..3008004 - 228 WP_003899421.1 hypothetical protein -
FPJ55_RS14070 3008001..3008390 - 390 WP_003899422.1 hypothetical protein -
FPJ55_RS14075 3008296..3008568 + 273 WP_003900544.1 hypothetical protein -
FPJ55_RS14080 3008667..3008900 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2998723..3007632 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T133225 WP_003899414.1 NZ_CP041853:c3003723-3003400 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T133225 NZ_CP041853:c3003723-3003400 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT133225 WP_003899415.1 NZ_CP041853:c3004048-3003803 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT133225 NZ_CP041853:c3004048-3003803 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References