Detailed information of TA system TA133193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-mazE/PIN(toxin)
• Location: 761502..762294
• Replicon: chromosome
• Accession: NZ_CP041853
• Organism: Mycobacterium tuberculosis strain 1-0107P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ55_RS03500
• Protein ID: WP_193056061.1
• Coordinates: 761857..762294 (-)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: G0TQE0
• Locus tag: FPJ55_RS03495
• Protein ID: WP_003403381.1
• Coordinates: 761502..761747 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ55_RS03465	756573..758027	+	1455	WP_049955505.1	carotenoid cleavage oxygenase	-
FPJ55_RS03470	758108..759118	+	1011	WP_003911248.1	ABC transporter ATP-binding protein	-
FPJ55_RS03475	759506..759889	-	384	WP_015629650.1	hypothetical protein	-
FPJ55_RS03480	759984..760139	-	156	WP_003403368.1	type II toxin-antitoxin system VapB family antitoxin	-
FPJ55_RS03485	760215..760931	-	717	WP_003403371.1	CPBP family intramembrane metalloprotease	-
FPJ55_RS03490	761207..761515	-	309	WP_003403376.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FPJ55_RS03495	761502..761747	-	246	WP_003403381.1	ribbon-helix-helix protein, CopG family	Antitoxin
FPJ55_RS03500	761857..762294	-	438	WP_193056061.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ55_RS03505	762291..762545	-	255	WP_003911263.1	antitoxin VapB7	-
FPJ55_RS03510	762659..765022	+	2364	WP_003403397.1	arylsulfatase AtsD	-
FPJ55_RS03515	765085..765411	+	327	WP_003403401.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FPJ55_RS03520	765323..765661	+	339	WP_003403405.1	PIN domain-containing protein	-
FPJ55_RS03525	765658..765831	+	174	WP_003898549.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15273.45 Da
• Isoelectric Point: 5.1865

>T133193 WP_193056061.1 NZ_CP041853:c762294-761857 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDVAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Nucleotide

• Length: 438 bp

>T133193 NZ_CP041853:c762294-761857 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGTCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9169.01 Da
• Isoelectric Point: 4.2070

>AT133193 WP_003403381.1 NZ_CP041853:c761747-761502 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Nucleotide

• Length: 246 bp

>AT133193 NZ_CP041853:c761747-761502 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Antitoxin

• AlphaFold DB: G0TQE0