Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1691880..1692496 Replicon chromosome
Accession NZ_CP041850
Organism Mycobacterium tuberculosis strain 1-0116P6C4

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag FPJ58_RS07870 Protein ID WP_003407593.1
Coordinates 1692179..1692496 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag FPJ58_RS07865 Protein ID WP_003900349.1
Coordinates 1691880..1692182 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ58_RS07855 1687766..1689613 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
FPJ58_RS07860 1689614..1691866 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
FPJ58_RS07865 1691880..1692182 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
FPJ58_RS07870 1692179..1692496 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
FPJ58_RS07875 1692493..1693497 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
FPJ58_RS07880 1693550..1694839 + 1290 WP_003902090.1 serine hydrolase -
FPJ58_RS07885 1694912..1695685 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
FPJ58_RS07890 1695743..1695955 - 213 WP_003898900.1 dodecin family protein -
FPJ58_RS07895 1695965..1696189 - 225 WP_160522526.1 NUDIX domain-containing protein -
FPJ58_RS07900 1696459..1697487 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T133026 WP_003407593.1 NZ_CP041850:1692179-1692496 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T133026 NZ_CP041850:1692179-1692496 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT133026 WP_003900349.1 NZ_CP041850:1691880-1692182 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT133026 NZ_CP041850:1691880-1692182 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References