Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1581046..1581701 Replicon chromosome
Accession NZ_CP041833
Organism Mycobacterium tuberculosis strain 2-0046P6C4

Toxin (Protein)


Gene name vapC Uniprot ID A0A654ZI33
Locus tag FPJ75_RS07360 Protein ID WP_031581039.1
Coordinates 1581046..1581447 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag FPJ75_RS07365 Protein ID WP_003407272.1
Coordinates 1581444..1581701 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ75_RS07345 1576518..1577903 - 1386 WP_003407260.1 cytochrome P450 -
FPJ75_RS07350 1577981..1579015 + 1035 WP_003407264.1 AraC family transcriptional regulator -
FPJ75_RS07355 1579061..1580791 - 1731 WP_009940170.1 PE family protein -
FPJ75_RS07360 1581046..1581447 - 402 WP_031581039.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ75_RS07365 1581444..1581701 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ75_RS07370 1581784..1582743 - 960 WP_003407276.1 alpha/beta hydrolase -
FPJ75_RS07375 1582768..1583730 - 963 WP_003407279.1 alpha/beta hydrolase -
FPJ75_RS07380 1583729..1584466 + 738 WP_031647000.1 lysoplasmalogenase -
FPJ75_RS07385 1584547..1586514 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14982.46 Da        Isoelectric Point: 11.1839

>T131997 WP_031581039.1 NZ_CP041833:c1581447-1581046 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPWA

Download         Length: 402 bp

>T131997 NZ_CP041833:c1581447-1581046 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGTGGGCAT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT131997 WP_003407272.1 NZ_CP041833:c1581701-1581444 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT131997 NZ_CP041833:c1581701-1581444 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654ZI33

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References