Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2973380..2974028 Replicon chromosome
Accession NZ_CP041824
Organism Mycobacterium tuberculosis strain 4-0012P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ84_RS13850 Protein ID WP_003899414.1
Coordinates 2973380..2973703 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ84_RS13855 Protein ID WP_003899415.1
Coordinates 2973783..2974028 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ84_RS13820 2968703..2969701 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ84_RS13825 2969715..2970179 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ84_RS13830 2970167..2970418 + 252 WP_003908028.1 hypothetical protein -
FPJ84_RS13835 2970589..2972028 - 1440 WP_003899411.1 phage major capsid protein -
FPJ84_RS13840 2972036..2972569 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ84_RS13845 2972722..2973213 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ84_RS13850 2973380..2973703 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ84_RS13855 2973783..2974028 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ84_RS13860 2974025..2975452 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ84_RS13865 2975454..2975846 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ84_RS13870 2975843..2976103 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ84_RS13875 2976120..2976482 - 363 WP_003900543.1 hypothetical protein -
FPJ84_RS13880 2976485..2977612 - 1128 WP_003899420.1 site-specific integrase -
FPJ84_RS13885 2977757..2977984 - 228 WP_003899421.1 hypothetical protein -
FPJ84_RS13890 2977981..2978370 - 390 WP_003899422.1 hypothetical protein -
FPJ84_RS13895 2978276..2978548 + 273 WP_003900544.1 hypothetical protein -
FPJ84_RS13900 2978647..2978880 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2968703..2977612 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Toxin HigB-like

(11-90)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T131476 WP_003899414.1 NZ_CP041824:c2973703-2973380 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T131476 NZ_CP041824:c2973703-2973380 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131476 WP_003899415.1 NZ_CP041824:c2974028-2973783 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131476 NZ_CP041824:c2974028-2973783 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References