Detailed information of TA system TA131458

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1963175..1963635
• Replicon: chromosome
• Accession: NZ_CP041824
• Organism: Mycobacterium tuberculosis strain 4-0012P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TKL9
• Locus tag: FPJ84_RS09045
• Protein ID: WP_003898996.1
• Coordinates: 1963387..1963635 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPJ84_RS09040
• Protein ID: WP_031695221.1
• Coordinates: 1963175..1963387 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ84_RS09025	1959653..1960840	-	1188	WP_003898992.1	nitrate transporter NarK	-
FPJ84_RS09030	1961127..1961411	+	285	WP_003408522.1	DUF1876 domain-containing protein	-
FPJ84_RS09035	1961425..1963107	-	1683	WP_003898994.1	SulP family inorganic anion transporter	-
FPJ84_RS09040	1963175..1963387	+	213	WP_031695221.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPJ84_RS09045	1963387..1963635	+	249	WP_003898996.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ84_RS09050	1963643..1964380	+	738	WP_003898997.1	hypothetical protein	-
FPJ84_RS09055	1964474..1966174	+	1701	WP_003898998.1	serine/threonine protein kinase PknE	-
FPJ84_RS09060	1966459..1966860	-	402	WP_003408538.1	hypothetical protein	-
FPJ84_RS09065	1966850..1967461	-	612	WP_003898999.1	isopentenyl-diphosphate Delta-isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin VapB-like (2-69)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 8884.14 Da
• Isoelectric Point: 4.1074

>T131458 WP_003898996.1 NZ_CP041824:1963387-1963635 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Nucleotide

• Length: 249 bp

>T131458 NZ_CP041824:1963387-1963635 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7606.81 Da
• Isoelectric Point: 10.7460

>AT131458 WP_031695221.1 NZ_CP041824:1963175-1963387 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDQRGLPA

Nucleotide

• Length: 213 bp

>AT131458 NZ_CP041824:1963175-1963387 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACCAGCGCGGGTTGCCCGCCTGA

Structures

Toxin

• AlphaFold DB: G0TKL9