Detailed information of TA system TA131441

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 757946..758579
• Replicon: chromosome
• Accession: NZ_CP041824
• Organism: Mycobacterium tuberculosis strain 4-0012P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ84_RS03465
• Protein ID: WP_031695162.1
• Coordinates: 757946..758329 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ56
• Locus tag: FPJ84_RS03470
• Protein ID: WP_003403368.1
• Coordinates: 758424..758579 (-)
• Length: 52 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ84_RS03440	753238..753774	+	537	WP_003403341.1	50S ribosomal protein L10	-
FPJ84_RS03445	753811..754203	+	393	WP_003403353.1	50S ribosomal protein L7/L12	-
FPJ84_RS03450	754196..754891	-	696	WP_003403355.1	TetR/AcrR family transcriptional regulator	-
FPJ84_RS03455	754962..756467	+	1506	WP_003403360.1	carotenoid cleavage oxygenase	-
FPJ84_RS03460	756548..757558	+	1011	WP_003911248.1	ABC transporter ATP-binding protein	-
FPJ84_RS03465	757946..758329	-	384	WP_031695162.1	ribonuclease	Toxin
FPJ84_RS03470	758424..758579	-	156	WP_003403368.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPJ84_RS03475	758655..759371	-	717	WP_003403371.1	CPBP family intramembrane metalloprotease	-
FPJ84_RS03480	759647..759955	-	309	WP_003403376.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FPJ84_RS03485	759942..760187	-	246	WP_003403381.1	ribbon-helix-helix protein, CopG family	-
FPJ84_RS03490	760297..760734	-	438	WP_003403386.1	type II toxin-antitoxin system VapC family toxin	-
FPJ84_RS03495	760731..760985	-	255	WP_003911263.1	antitoxin VapB7	-
FPJ84_RS03500	761099..763462	+	2364	WP_031695163.1	arylsulfatase AtsD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-44)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 13940.69 Da
• Isoelectric Point: 5.9766

>T131441 WP_031695162.1 NZ_CP041824:c758329-757946 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHHLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Nucleotide

• Length: 384 bp

>T131441 NZ_CP041824:c758329-757946 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCACCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 52 a.a.
• Molecular weight: 5872.72 Da
• Isoelectric Point: 5.7734

>AT131441 WP_003403368.1 NZ_CP041824:c758579-758424 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Nucleotide

• Length: 156 bp

>AT131441 NZ_CP041824:c758579-758424 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BSF8