Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2372585..2373280 Replicon chromosome
Accession NZ_CP041818
Organism Mycobacterium tuberculosis strain 4-0087P6C4

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag FPJ91_RS10965 Protein ID WP_003410811.1
Coordinates 2372585..2373019 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag FPJ91_RS10970 Protein ID WP_003410814.1
Coordinates 2373026..2373280 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ91_RS10950 2368774..2370312 + 1539 WP_023637436.1 HNH endonuclease -
FPJ91_RS10955 2370511..2372181 + 1671 Protein_2166 ATP-dependent helicase -
FPJ91_RS10960 2372184..2372606 + 423 Protein_2167 SWIM zinc finger family protein -
FPJ91_RS10965 2372585..2373019 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ91_RS10970 2373026..2373280 - 255 WP_003410814.1 antitoxin Antitoxin
FPJ91_RS10975 2373296..2373553 - 258 WP_003410816.1 hypothetical protein -
FPJ91_RS10980 2374500..2374796 + 297 WP_003410820.1 PE family protein -
FPJ91_RS10985 2374852..2375583 + 732 WP_003900467.1 PPE family protein -
FPJ91_RS10990 2376123..2376869 - 747 WP_003899174.1 proteasome subunit alpha -
FPJ91_RS10995 2376866..2377741 - 876 WP_003411023.1 proteasome subunit beta -
FPJ91_RS11000 2377738..2377932 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T131102 WP_003410811.1 NZ_CP041818:c2373019-2372585 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T131102 NZ_CP041818:c2373019-2372585 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT131102 WP_003410814.1 NZ_CP041818:c2373280-2373026 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT131102 NZ_CP041818:c2373280-2373026 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References