Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3701115..3701740 Replicon chromosome
Accession NZ_CP041815
Organism Mycobacterium tuberculosis strain SEA02010036P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FPJ94_RS17355 Protein ID WP_003403218.1
Coordinates 3701115..3701516 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FPJ94_RS17360 Protein ID WP_003403213.1
Coordinates 3701513..3701740 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ94_RS17330 3696205..3697152 - 948 WP_003403232.1 DUF732 domain-containing protein -
FPJ94_RS17335 3697256..3698320 - 1065 WP_003898532.1 hypothetical protein -
FPJ94_RS17340 3698715..3699806 - 1092 WP_003900977.1 galactokinase -
FPJ94_RS17345 3699803..3700294 - 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
FPJ94_RS17350 3700291..3700986 - 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
FPJ94_RS17355 3701115..3701516 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FPJ94_RS17360 3701513..3701740 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FPJ94_RS17365 3701935..3702177 - 243 WP_003403210.1 hypothetical protein -
FPJ94_RS17370 3702174..3702923 - 750 WP_003898528.1 hypothetical protein -
FPJ94_RS17375 3703007..3705574 + 2568 WP_003901879.1 SEC-C domain-containing protein -
FPJ94_RS17380 3705593..3706198 - 606 WP_003898526.1 hypothetical protein -
FPJ94_RS17385 3706340..3706561 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T130937 WP_003403218.1 NZ_CP041815:c3701516-3701115 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T130937 NZ_CP041815:c3701516-3701115 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT130937 WP_003403213.1 NZ_CP041815:c3701740-3701513 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT130937 NZ_CP041815:c3701740-3701513 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References