Detailed information of TA system TA130929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 3396986..3397605
• Replicon: chromosome
• Accession: NZ_CP041815
• Organism: Mycobacterium tuberculosis strain SEA02010036P6C4

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: FPJ94_RS15800
• Protein ID: WP_003404726.1
• Coordinates: 3396986..3397420 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: P9WJ06
• Locus tag: FPJ94_RS15805
• Protein ID: WP_003898641.1
• Coordinates: 3397426..3397605 (-)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ94_RS15775	3392321..3393559	+	1239	WP_003404744.1	acetyl-CoA acetyltransferase	-
FPJ94_RS15780	3393561..3395069	+	1509	WP_003404742.1	carotenoid oxygenase family protein	-
FPJ94_RS15785	3395236..3395466	+	231	WP_003898642.1	hypothetical protein	-
FPJ94_RS15790	3395601..3396050	-	450	WP_003404738.1	hypothetical protein	-
FPJ94_RS15795	3396115..3396888	-	774	WP_003404735.1	VOC family protein	-
FPJ94_RS15800	3396986..3397420	-	435	WP_003404726.1	SRPBCC family protein	Toxin
FPJ94_RS15805	3397426..3397605	-	180	WP_003898641.1	antitoxin	Antitoxin
FPJ94_RS15810	3397731..3397889	-	159	WP_003404720.1	hypothetical protein	-
FPJ94_RS15815	3398162..3400555	-	2394	WP_003898639.1	cation-translocating P-type ATPase	-
FPJ94_RS15820	3400552..3402132	-	1581	WP_003910977.1	serine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-50)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15754.47 Da
• Isoelectric Point: 9.7977

>T130929 WP_003404726.1 NZ_CP041815:c3397420-3396986 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Nucleotide

• Length: 435 bp

>T130929 NZ_CP041815:c3397420-3396986 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6403.07 Da
• Isoelectric Point: 4.5393

>AT130929 WP_003898641.1 NZ_CP041815:c3397605-3397426 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Nucleotide

• Length: 180 bp

>AT130929 NZ_CP041815:c3397605-3397426 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Structures

Antitoxin

• AlphaFold DB: A0A045KDK5