Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1721666..1722279 Replicon chromosome
Accession NZ_CP041815
Organism Mycobacterium tuberculosis strain SEA02010036P6C4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FPJ94_RS07800 Protein ID WP_003910864.1
Coordinates 1721666..1722055 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FPJ94_RS07805 Protein ID WP_003408469.1
Coordinates 1722052..1722279 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ94_RS07770 1717295..1718209 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
FPJ94_RS07775 1718212..1719042 + 831 WP_003408448.1 cyclase family protein -
FPJ94_RS07780 1719042..1719392 + 351 WP_003898986.1 cupin domain-containing protein -
FPJ94_RS07785 1719445..1720263 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
FPJ94_RS07790 1720277..1721056 + 780 WP_003408460.1 IclR family transcriptional regulator -
FPJ94_RS07800 1721666..1722055 - 390 WP_003910864.1 PIN domain-containing protein Toxin
FPJ94_RS07805 1722052..1722279 - 228 WP_003408469.1 antitoxin Antitoxin
FPJ94_RS07810 1722497..1723981 + 1485 WP_003408473.1 carboxylase -
FPJ94_RS07815 1723978..1725225 + 1248 WP_003408476.1 serine hydrolase -
FPJ94_RS07820 1725268..1725687 - 420 WP_003408483.1 hypothetical protein -
FPJ94_RS07825 1725677..1726387 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13837.02 Da        Isoelectric Point: 7.4232

>T130899 WP_003910864.1 NZ_CP041815:c1722055-1721666 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVRAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T130899 NZ_CP041815:c1722055-1721666 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCGCGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT130899 WP_003408469.1 NZ_CP041815:c1722279-1722052 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT130899 NZ_CP041815:c1722279-1722052 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References