Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1468766..1469382 Replicon chromosome
Accession NZ_CP041815
Organism Mycobacterium tuberculosis strain SEA02010036P6C4

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag FPJ94_RS06710 Protein ID WP_003407593.1
Coordinates 1469065..1469382 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag FPJ94_RS06705 Protein ID WP_003900349.1
Coordinates 1468766..1469068 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ94_RS06695 1464652..1466499 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
FPJ94_RS06700 1466500..1468752 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
FPJ94_RS06705 1468766..1469068 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
FPJ94_RS06710 1469065..1469382 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
FPJ94_RS06715 1469379..1470383 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
FPJ94_RS06720 1470436..1471725 + 1290 WP_003902090.1 serine hydrolase -
FPJ94_RS06725 1471798..1472571 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
FPJ94_RS06730 1472629..1472841 - 213 WP_003898900.1 dodecin family protein -
FPJ94_RS06735 1472851..1473075 - 225 WP_160522526.1 NUDIX domain-containing protein -
FPJ94_RS06740 1473345..1474373 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T130897 WP_003407593.1 NZ_CP041815:1469065-1469382 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T130897 NZ_CP041815:1469065-1469382 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT130897 WP_003900349.1 NZ_CP041815:1468766-1469068 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT130897 NZ_CP041815:1468766-1469068 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References