Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2976893..2977541 Replicon chromosome
Accession NZ_CP041812
Organism Mycobacterium tuberculosis strain SEA07020250P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ97_RS13920 Protein ID WP_003899414.1
Coordinates 2976893..2977216 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ97_RS13925 Protein ID WP_003899415.1
Coordinates 2977296..2977541 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ97_RS13890 2972216..2973214 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ97_RS13895 2973228..2973692 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ97_RS13900 2973680..2973931 + 252 WP_003908028.1 hypothetical protein -
FPJ97_RS13905 2974102..2975541 - 1440 WP_003899411.1 phage major capsid protein -
FPJ97_RS13910 2975549..2976082 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ97_RS13915 2976235..2976726 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ97_RS13920 2976893..2977216 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ97_RS13925 2977296..2977541 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ97_RS13930 2977538..2978965 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ97_RS13935 2978967..2979359 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ97_RS13940 2979356..2979616 - 261 WP_014585547.1 helix-turn-helix domain-containing protein -
FPJ97_RS13945 2979633..2979995 - 363 WP_003900543.1 hypothetical protein -
FPJ97_RS13950 2979998..2981125 - 1128 WP_003899420.1 site-specific integrase -
FPJ97_RS13955 2981270..2981497 - 228 WP_003899421.1 hypothetical protein -
FPJ97_RS13960 2981494..2981883 - 390 WP_003899422.1 hypothetical protein -
FPJ97_RS13965 2981789..2982061 + 273 WP_003900544.1 hypothetical protein -
FPJ97_RS13970 2982160..2982393 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2972216..2981125 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T130747 WP_003899414.1 NZ_CP041812:c2977216-2976893 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T130747 NZ_CP041812:c2977216-2976893 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130747 WP_003899415.1 NZ_CP041812:c2977541-2977296 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130747 NZ_CP041812:c2977541-2977296 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References