Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2963437..2964085 Replicon chromosome
Accession NZ_CP041809
Organism Mycobacterium tuberculosis strain SEA09020048P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPK00_RS13825 Protein ID WP_003899414.1
Coordinates 2963437..2963760 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPK00_RS13830 Protein ID WP_003899415.1
Coordinates 2963840..2964085 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK00_RS13795 2958760..2959758 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPK00_RS13800 2959772..2960236 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPK00_RS13805 2960224..2960475 + 252 WP_003908028.1 hypothetical protein -
FPK00_RS13810 2960646..2962085 - 1440 WP_003899411.1 phage major capsid protein -
FPK00_RS13815 2962093..2962626 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPK00_RS13820 2962779..2963270 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPK00_RS13825 2963437..2963760 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPK00_RS13830 2963840..2964085 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPK00_RS13835 2964082..2965509 - 1428 WP_193020002.1 DUF3631 domain-containing protein -
FPK00_RS13840 2965511..2965903 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPK00_RS13845 2965900..2966160 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPK00_RS13850 2966177..2966539 - 363 WP_003900543.1 hypothetical protein -
FPK00_RS13855 2966542..2967669 - 1128 WP_003899420.1 site-specific integrase -
FPK00_RS13860 2967814..2968041 - 228 WP_003899421.1 hypothetical protein -
FPK00_RS13865 2968038..2968427 - 390 WP_003899422.1 hypothetical protein -
FPK00_RS13870 2968333..2968605 + 273 WP_003900544.1 hypothetical protein -
FPK00_RS13875 2968704..2968937 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2958760..2967669 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T130564 WP_003899414.1 NZ_CP041809:c2963760-2963437 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T130564 NZ_CP041809:c2963760-2963437 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130564 WP_003899415.1 NZ_CP041809:c2964085-2963840 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130564 NZ_CP041809:c2964085-2963840 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References