Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2961269..2961917 Replicon chromosome
Accession NZ_CP041808
Organism Mycobacterium tuberculosis strain SEA09167P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPK01_RS13830 Protein ID WP_003899414.1
Coordinates 2961269..2961592 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPK01_RS13835 Protein ID WP_003899415.1
Coordinates 2961672..2961917 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK01_RS13800 2956592..2957590 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPK01_RS13805 2957604..2958068 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPK01_RS13810 2958056..2958307 + 252 WP_003908028.1 hypothetical protein -
FPK01_RS13815 2958478..2959917 - 1440 WP_003899411.1 phage major capsid protein -
FPK01_RS13820 2959925..2960458 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPK01_RS13825 2960611..2961102 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPK01_RS13830 2961269..2961592 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPK01_RS13835 2961672..2961917 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPK01_RS13840 2961914..2963341 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPK01_RS13845 2963343..2963735 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPK01_RS13850 2963732..2963992 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPK01_RS13855 2964009..2964371 - 363 WP_003900543.1 hypothetical protein -
FPK01_RS13860 2964374..2965501 - 1128 WP_003899420.1 site-specific integrase -
FPK01_RS13865 2965646..2965873 - 228 WP_003899421.1 hypothetical protein -
FPK01_RS13870 2965870..2966259 - 390 WP_003899422.1 hypothetical protein -
FPK01_RS13875 2966165..2966437 + 273 WP_003900544.1 hypothetical protein -
FPK01_RS13880 2966536..2966769 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2956592..2965501 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T130503 WP_003899414.1 NZ_CP041808:c2961592-2961269 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T130503 NZ_CP041808:c2961592-2961269 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130503 WP_003899415.1 NZ_CP041808:c2961917-2961672 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130503 NZ_CP041808:c2961917-2961672 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References