Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2973005..2973653 Replicon chromosome
Accession NZ_CP041805
Organism Mycobacterium tuberculosis strain SEA11020068P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPK04_RS13860 Protein ID WP_003899414.1
Coordinates 2973005..2973328 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPK04_RS13865 Protein ID WP_003899415.1
Coordinates 2973408..2973653 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK04_RS13830 2968329..2969327 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPK04_RS13835 2969341..2969805 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPK04_RS13840 2969793..2970044 + 252 WP_003908028.1 hypothetical protein -
FPK04_RS13845 2970215..2971654 - 1440 WP_003899411.1 phage major capsid protein -
FPK04_RS13850 2971662..2972195 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPK04_RS13855 2972348..2972839 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPK04_RS13860 2973005..2973328 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPK04_RS13865 2973408..2973653 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPK04_RS13870 2973650..2975077 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPK04_RS13875 2975079..2975471 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPK04_RS13880 2975468..2975728 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPK04_RS13885 2975745..2976107 - 363 WP_003900543.1 hypothetical protein -
FPK04_RS13890 2976110..2977237 - 1128 WP_003899420.1 site-specific integrase -
FPK04_RS13895 2977382..2977609 - 228 WP_003899421.1 hypothetical protein -
FPK04_RS13900 2977606..2977995 - 390 WP_003899422.1 hypothetical protein -
FPK04_RS13905 2977901..2978173 + 273 WP_003900544.1 hypothetical protein -
FPK04_RS13910 2978272..2978505 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2968329..2977237 8908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T130322 WP_003899414.1 NZ_CP041805:c2973328-2973005 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T130322 NZ_CP041805:c2973328-2973005 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130322 WP_003899415.1 NZ_CP041805:c2973653-2973408 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130322 NZ_CP041805:c2973653-2973408 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References