Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2976638..2977286 Replicon chromosome
Accession NZ_CP041804
Organism Mycobacterium tuberculosis strain SEA11020092P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPK05_RS13930 Protein ID WP_003899414.1
Coordinates 2976638..2976961 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPK05_RS13935 Protein ID WP_003899415.1
Coordinates 2977041..2977286 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK05_RS13900 2971961..2972959 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPK05_RS13905 2972973..2973437 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPK05_RS13910 2973425..2973676 + 252 WP_003908028.1 hypothetical protein -
FPK05_RS13915 2973847..2975286 - 1440 WP_003899411.1 phage major capsid protein -
FPK05_RS13920 2975294..2975827 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPK05_RS13925 2975980..2976471 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPK05_RS13930 2976638..2976961 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPK05_RS13935 2977041..2977286 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPK05_RS13940 2977283..2978710 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPK05_RS13945 2978712..2979104 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPK05_RS13950 2979101..2979361 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPK05_RS13955 2979378..2979740 - 363 WP_003900543.1 hypothetical protein -
FPK05_RS13960 2979743..2980870 - 1128 WP_003899420.1 site-specific integrase -
FPK05_RS13965 2981015..2981242 - 228 WP_003899421.1 hypothetical protein -
FPK05_RS13970 2981239..2981628 - 390 WP_003899422.1 hypothetical protein -
FPK05_RS13975 2981534..2981806 + 273 WP_003900544.1 hypothetical protein -
FPK05_RS13980 2981905..2982138 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2971961..2980870 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T130261 WP_003899414.1 NZ_CP041804:c2976961-2976638 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T130261 NZ_CP041804:c2976961-2976638 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130261 WP_003899415.1 NZ_CP041804:c2977286-2977041 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130261 NZ_CP041804:c2977286-2977041 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References