Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2999664..3000312 Replicon chromosome
Accession NZ_CP041801
Organism Mycobacterium tuberculosis strain SEA12202P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPK08_RS13970 Protein ID WP_003903987.1
Coordinates 2999664..2999987 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPK08_RS13975 Protein ID WP_003899415.1
Coordinates 3000067..3000312 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK08_RS13940 2994987..2995985 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
FPK08_RS13945 2995999..2996463 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPK08_RS13950 2996451..2996702 + 252 WP_003908028.1 hypothetical protein -
FPK08_RS13955 2996873..2998312 - 1440 WP_031658632.1 phage major capsid protein -
FPK08_RS13960 2998320..2998853 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPK08_RS13965 2999006..2999497 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPK08_RS13970 2999664..2999987 - 324 WP_003903987.1 type II toxin-antitoxin system toxin Toxin
FPK08_RS13975 3000067..3000312 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPK08_RS13980 3000309..3001736 - 1428 WP_003908030.1 DUF3631 domain-containing protein -
FPK08_RS13985 3001738..3002130 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPK08_RS13990 3002127..3002387 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPK08_RS13995 3002404..3002766 - 363 WP_003900543.1 hypothetical protein -
FPK08_RS14000 3002769..3003896 - 1128 WP_031674413.1 site-specific integrase -
FPK08_RS14005 3004041..3004268 - 228 WP_003899421.1 hypothetical protein -
FPK08_RS14010 3004265..3004654 - 390 WP_003899422.1 hypothetical protein -
FPK08_RS14015 3004560..3004832 + 273 WP_003900544.1 hypothetical protein -
FPK08_RS14020 3004931..3005164 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2994987..3003896 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12353.82 Da        Isoelectric Point: 7.4705

>T130082 WP_003903987.1 NZ_CP041801:c2999987-2999664 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T130082 NZ_CP041801:c2999987-2999664 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130082 WP_003899415.1 NZ_CP041801:c3000312-3000067 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130082 NZ_CP041801:c3000312-3000067 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References