Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3702950..3703624 Replicon chromosome
Accession NZ_CP041798
Organism Mycobacterium tuberculosis strain SEA13111P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPK11_RS17275 Protein ID WP_003417282.1
Coordinates 3702950..3703378 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPK11_RS17280 Protein ID WP_003417286.1
Coordinates 3703382..3703624 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK11_RS17250 3698772..3699173 - 402 WP_003417264.1 cytidine deaminase -
FPK11_RS17255 3699314..3699748 + 435 WP_072460198.1 succinate dehydrogenase, cytochrome b556 subunit -
FPK11_RS17260 3699745..3700179 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPK11_RS17265 3700308..3702080 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPK11_RS17270 3702080..3702871 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPK11_RS17275 3702950..3703378 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK11_RS17280 3703382..3703624 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPK11_RS17285 3703746..3704360 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPK11_RS17290 3704357..3705022 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPK11_RS17295 3705023..3705556 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPK11_RS17300 3705553..3705927 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPK11_RS17305 3706024..3707088 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T129911 WP_003417282.1 NZ_CP041798:c3703378-3702950 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T129911 NZ_CP041798:c3703378-3702950 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT129911 WP_003417286.1 NZ_CP041798:c3703624-3703382 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT129911 NZ_CP041798:c3703624-3703382 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References