Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203490..2204034 Replicon chromosome
Accession NZ_CP041798
Organism Mycobacterium tuberculosis strain SEA13111P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FPK11_RS10135 Protein ID WP_003409896.1
Coordinates 2203490..2203786 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPK11_RS10140 Protein ID WP_003409899.1
Coordinates 2203783..2204034 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK11_RS10080 2198523..2198873 - 351 WP_003409871.1 hypothetical protein -
FPK11_RS10085 2198884..2199786 - 903 WP_003409874.1 hypothetical protein -
FPK11_RS10090 2199807..2199998 - 192 WP_003409876.1 hypothetical protein -
FPK11_RS10095 2199999..2200295 - 297 WP_003409877.1 hypothetical protein -
FPK11_RS10100 2200535..2200750 + 216 WP_003409878.1 antitoxin -
FPK11_RS10105 2200747..2201058 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPK11_RS10110 2201032..2201553 - 522 WP_003904745.1 hypothetical protein -
FPK11_RS10115 2201528..2201905 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FPK11_RS10120 2201947..2202396 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FPK11_RS10125 2202393..2202938 + 546 WP_003409891.1 SecB-like chaperone -
FPK11_RS10130 2202827..2203441 - 615 WP_003901296.1 hypothetical protein -
FPK11_RS10135 2203490..2203786 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPK11_RS10140 2203783..2204034 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FPK11_RS10145 2204021..2204515 + 495 WP_003899099.1 hypothetical protein -
FPK11_RS10150 2204675..2205082 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPK11_RS10155 2205086..2205358 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPK11_RS10160 2205391..2206611 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FPK11_RS10165 2207510..2208307 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T129888 WP_003409896.1 NZ_CP041798:c2203786-2203490 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T129888 NZ_CP041798:c2203786-2203490 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT129888 WP_003409899.1 NZ_CP041798:c2204034-2203783 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT129888 NZ_CP041798:c2204034-2203783 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References