Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-RHH |
Location | 2203490..2204034 | Replicon | chromosome |
Accession | NZ_CP041798 | ||
Organism | Mycobacterium tuberculosis strain SEA13111P6C4 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TLU9 |
Locus tag | FPK11_RS10135 | Protein ID | WP_003409896.1 |
Coordinates | 2203490..2203786 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P67299 |
Locus tag | FPK11_RS10140 | Protein ID | WP_003409899.1 |
Coordinates | 2203783..2204034 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPK11_RS10080 | 2198523..2198873 | - | 351 | WP_003409871.1 | hypothetical protein | - |
FPK11_RS10085 | 2198884..2199786 | - | 903 | WP_003409874.1 | hypothetical protein | - |
FPK11_RS10090 | 2199807..2199998 | - | 192 | WP_003409876.1 | hypothetical protein | - |
FPK11_RS10095 | 2199999..2200295 | - | 297 | WP_003409877.1 | hypothetical protein | - |
FPK11_RS10100 | 2200535..2200750 | + | 216 | WP_003409878.1 | antitoxin | - |
FPK11_RS10105 | 2200747..2201058 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
FPK11_RS10110 | 2201032..2201553 | - | 522 | WP_003904745.1 | hypothetical protein | - |
FPK11_RS10115 | 2201528..2201905 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
FPK11_RS10120 | 2201947..2202396 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
FPK11_RS10125 | 2202393..2202938 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
FPK11_RS10130 | 2202827..2203441 | - | 615 | WP_003901296.1 | hypothetical protein | - |
FPK11_RS10135 | 2203490..2203786 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
FPK11_RS10140 | 2203783..2204034 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
FPK11_RS10145 | 2204021..2204515 | + | 495 | WP_003899099.1 | hypothetical protein | - |
FPK11_RS10150 | 2204675..2205082 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
FPK11_RS10155 | 2205086..2205358 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
FPK11_RS10160 | 2205391..2206611 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
FPK11_RS10165 | 2207510..2208307 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T129888 WP_003409896.1 NZ_CP041798:c2203786-2203490 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T129888 NZ_CP041798:c2203786-2203490 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT129888 WP_003409899.1 NZ_CP041798:c2204034-2203783 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT129888 NZ_CP041798:c2204034-2203783 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TLU9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BUZ2 |