Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3594048..3595666 Replicon chromosome
Accession NZ_CP041783
Organism Shewanella donghaensis strain LT17

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FPK91_RS15530 Protein ID WP_144212156.1
Coordinates 3594329..3595666 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FPK91_RS15525 Protein ID WP_144212155.1
Coordinates 3594048..3594329 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK91_RS15505 3589629..3590309 + 681 WP_144212152.1 pyrimidine 5'-nucleotidase -
FPK91_RS15510 3590417..3591919 - 1503 WP_193559170.1 chemotaxis protein -
FPK91_RS15515 3591929..3592549 - 621 WP_144212153.1 SCO family protein -
FPK91_RS15520 3592783..3593655 - 873 WP_144212154.1 mechanosensitive ion channel family protein -
FPK91_RS15525 3594048..3594329 + 282 WP_144212155.1 helix-turn-helix domain-containing protein Antitoxin
FPK91_RS15530 3594329..3595666 + 1338 WP_144212156.1 type II toxin-antitoxin system HipA family toxin Toxin
FPK91_RS15535 3595807..3597060 + 1254 WP_144212157.1 DNA cytosine methyltransferase -
FPK91_RS15540 3597905..3599200 + 1296 WP_144214472.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 49499.87 Da        Isoelectric Point: 7.9763

>T129251 WP_144212156.1 NZ_CP041783:3594329-3595666 [Shewanella donghaensis]
MATLDVYMNGYLIGEFTKSSSGSHVFKYAAQWLNTADSRPISLSMPLRVQSYKGDEVYNFFDNLLPDNIEVRNRIVARHN
AQSTQAFDLLAKVGQDSVGALQFVPHGQLPLDVKNIESKPLSSSALEKVLRGYLSNIPLGMLTGEDDFRISIAGAQEKTA
LLNLDNAQINAWRLPIKATPTTHIIKLPIGKIQSHSHTIDMTNSVENEYLSMMIVREFGLAVPQCSILKVGDMKALVVAR
FDRKLSSDKQWIMRLPQEDFCQTLNVPSAKKYESHGGPGIEQIMNYLLGSTNATQDRYDFMKSQVLFWLLAATDGHAKNF
SLFIDAGGGYRLTPFYDILSIYPAIGGQGLNIRDAKLAMGLKATKGKKYAADKIFPRHFIQTAKAVGFDPKIMTDILQEV
ADSVEGVIHRVTAKLPDDFPEHIKESILNGLSERAKRLSMEESLQ

Download         Length: 1338 bp

>T129251 NZ_CP041783:3594329-3595666 [Shewanella donghaensis]
ATGGCCACGCTTGATGTTTATATGAATGGGTATTTGATTGGAGAGTTCACTAAATCTTCTAGCGGTTCGCATGTCTTTAA
GTATGCTGCGCAATGGTTAAATACAGCGGATAGTCGCCCTATTTCATTGTCTATGCCGTTACGAGTGCAAAGCTATAAAG
GCGATGAAGTATACAACTTTTTCGACAACCTTCTGCCAGATAATATTGAGGTCAGAAACAGAATTGTTGCTCGGCACAAT
GCACAATCTACCCAAGCATTCGATTTATTAGCCAAAGTGGGGCAAGACAGTGTCGGCGCGTTACAATTTGTGCCCCATGG
TCAACTCCCCTTGGATGTTAAGAACATTGAATCTAAACCGTTATCCAGCAGTGCATTGGAAAAAGTCTTACGAGGCTATC
TTTCAAATATTCCGCTAGGCATGCTAACAGGTGAAGATGACTTTCGAATATCCATTGCAGGCGCGCAAGAAAAAACCGCG
CTGTTGAACTTAGATAATGCACAAATAAATGCTTGGCGCCTACCGATTAAAGCCACACCAACAACACACATTATTAAATT
ACCTATTGGCAAAATACAAAGCCATTCACACACCATTGATATGACAAACAGTGTTGAAAATGAATACCTGAGCATGATGA
TAGTCAGGGAGTTTGGTTTAGCTGTGCCGCAATGCTCAATACTAAAAGTGGGCGATATGAAAGCGCTAGTAGTAGCACGT
TTTGACCGCAAACTATCATCAGACAAACAATGGATTATGCGCTTACCCCAAGAGGATTTTTGTCAAACATTGAATGTCCC
ATCGGCTAAAAAATACGAAAGCCATGGTGGACCGGGTATTGAACAAATAATGAATTACTTATTGGGCTCAACCAATGCCA
CACAAGATAGATACGATTTTATGAAATCCCAAGTGCTGTTTTGGTTGTTAGCAGCAACAGACGGGCACGCTAAAAACTTT
TCCTTGTTCATTGATGCTGGCGGCGGTTACAGGCTAACCCCTTTTTACGATATTTTATCCATATATCCAGCAATAGGTGG
GCAAGGATTAAATATTCGCGATGCCAAATTAGCTATGGGGCTTAAAGCGACTAAAGGTAAAAAGTATGCGGCAGATAAGA
TATTCCCCAGGCACTTTATCCAGACAGCTAAGGCAGTAGGATTTGATCCCAAAATCATGACTGACATTTTGCAAGAGGTC
GCAGATTCAGTGGAGGGGGTGATTCATCGAGTCACAGCCAAGTTACCAGATGATTTTCCTGAGCATATTAAAGAGTCGAT
TCTGAATGGATTAAGTGAAAGAGCTAAAAGGCTGTCAATGGAGGAGAGTCTTCAGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10512.95 Da        Isoelectric Point: 6.3472

>AT129251 WP_144212155.1 NZ_CP041783:3594048-3594329 [Shewanella donghaensis]
MKVTNSKQLSAFLKDTRLNMKLPQTKVASSVGIRQDTVSSFEQNPDSTKVETLFKILSALNLELDIKVRGSDPESQRMGD
DVKAAEVQWKEEW

Download         Length: 282 bp

>AT129251 NZ_CP041783:3594048-3594329 [Shewanella donghaensis]
ATGAAGGTAACAAACTCAAAGCAACTTAGCGCATTTCTCAAAGATACACGGCTGAATATGAAATTGCCTCAAACTAAAGT
GGCCAGTAGCGTGGGTATCCGCCAAGATACCGTTTCAAGCTTTGAGCAAAACCCTGATTCAACCAAAGTAGAAACCTTAT
TTAAAATCTTATCTGCATTAAACCTCGAACTCGACATCAAGGTGAGAGGTTCAGATCCGGAAAGTCAGCGAATGGGTGAT
GACGTCAAGGCTGCTGAAGTACAGTGGAAAGAGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References