Detailed information of TA system TA129240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2974305..2974870
• Replicon: chromosome
• Accession: NZ_CP041778
• Organism: Burkholderia sp. MS455

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ27_RS17635
• Protein ID: WP_175917054.1
• Coordinates: 2974499..2974870 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1K1SS38
• Locus tag: FPJ27_RS17630
• Protein ID: WP_072444647.1
• Coordinates: 2974305..2974502 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ27_RS17605	2969447..2969902	-	456	WP_072444612.1	RbsD/FucU family protein	-
FPJ27_RS17610	2969980..2970372	-	393	WP_072444610.1	nuclear transport factor 2 family protein	-
FPJ27_RS17615	2970591..2972144	-	1554	WP_204421970.1	galactarate dehydratase	-
FPJ27_RS17620	2972375..2973289	+	915	WP_034181775.1	5-dehydro-4-deoxyglucarate dehydratase	-
FPJ27_RS17625	2973488..2974039	-	552	WP_034181774.1	hypothetical protein	-
FPJ27_RS17630	2974305..2974502	+	198	WP_072444647.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPJ27_RS17635	2974499..2974870	+	372	WP_175917054.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ27_RS17640	2975004..2976581	-	1578	WP_204421971.1	aldehyde dehydrogenase (NADP(+))	-
FPJ27_RS17645	2976868..2978211	+	1344	WP_204423244.1	D-galactonate transporter	-
FPJ27_RS17650	2978286..2979011	-	726	WP_072444600.1	site-2 protease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13403.42 Da
• Isoelectric Point: 6.2125

>T129240 WP_175917054.1 NZ_CP041778:2974499-2974870 [Burkholderia sp. MS455]
MILVDTSVWIDHLRAGDAALTTLLEAERVLIHPFVVGELSLGSLRDRQTVLDALRDLPAATSATDDEVQRMIDVVPLHGL
GIGYVDAHLLASVRLTSGSKLWTRDRRLLAAADRLQLAAHPAH

Nucleotide

• Length: 372 bp

>T129240 NZ_CP041778:2974499-2974870 [Burkholderia sp. MS455]
ATGATTCTTGTCGACACGTCCGTCTGGATCGACCACCTGCGAGCCGGTGATGCGGCGCTCACTACGCTGCTCGAAGCCGA
GCGGGTATTGATCCATCCGTTCGTGGTCGGCGAGCTTTCGCTCGGCAGCCTGCGCGATCGCCAGACCGTGCTGGACGCGC
TGCGCGACCTCCCCGCTGCCACCTCGGCAACCGACGACGAGGTTCAACGCATGATCGATGTCGTGCCGCTTCACGGACTC
GGCATCGGTTACGTCGACGCGCACCTGCTCGCTTCAGTCAGACTGACCAGCGGCAGCAAGCTGTGGACACGCGACCGGCG
CCTGCTGGCCGCAGCCGACCGCCTGCAGCTCGCCGCTCACCCCGCCCACTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7064.14 Da
• Isoelectric Point: 10.6826

>AT129240 WP_072444647.1 NZ_CP041778:2974305-2974502 [Burkholderia sp. MS455]
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLEPVPRRPSEPA

Nucleotide

• Length: 198 bp

>AT129240 NZ_CP041778:2974305-2974502 [Burkholderia sp. MS455]
ATGCGCACCACCTTATCCCTGGACGACGCCCTGCTCGCCAAAGCGCAGCAGTTGACTGGCGTCACCGAAAAGTCGGCGCT
GGTAAGAGAAGCACTGCGCGCGCTGATTGCCCGCGAAAGCGCACGACGGCTGGCTCGTCTCGGCGGCACCGAACCCGATC
TCGAACCCGTGCCGCGCCGCCCGTCGGAGCCAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A1K1SS38