Detailed information of TA system TA129234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 1435446..1436079
• Replicon: chromosome
• Accession: NZ_CP041778
• Organism: Burkholderia sp. MS455

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ27_RS11090
• Protein ID: WP_204422904.1
• Coordinates: 1435666..1436079 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPJ27_RS11085
• Protein ID: WP_175959113.1
• Coordinates: 1435446..1435679 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ27_RS11075	1432106..1434406	+	2301	WP_204422903.1	ATP-dependent DNA helicase	-
FPJ27_RS11080	1434510..1435280	-	771	WP_072436791.1	helix-turn-helix domain-containing protein	-
FPJ27_RS11085	1435446..1435679	+	234	WP_175959113.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FPJ27_RS11090	1435666..1436079	+	414	WP_204422904.1	PIN domain-containing protein	Toxin
FPJ27_RS11095	1436139..1436750	+	612	WP_204422905.1	hypothetical protein	-
FPJ27_RS11100	1436879..1438180	-	1302	WP_034179537.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
FPJ27_RS11105	1438382..1439689	-	1308	WP_072436793.1	shikimate transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (10-119)

Antitoxin

• SpoVT-AbrB domain (5-37)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15167.34 Da
• Isoelectric Point: 5.5927

>T129234 WP_204422904.1 NZ_CP041778:1435666-1436079 [Burkholderia sp. MS455]
MSGIESAKSFVDSNIVLYLLSGDETKANRAEALFLRRPTISVQVLNEVASVCSRKLRMPWSDVGQFLEPIRSLCHVVPVT
IDTHDLARRLAERHGLSFYDACIVAAASLDGCEYLYTEDMHDGLRVDGGPVLRNPFA

Nucleotide

• Length: 414 bp

>T129234 NZ_CP041778:1435666-1436079 [Burkholderia sp. MS455]
ATGAGCGGGATTGAGTCGGCGAAGTCGTTCGTCGACAGCAATATCGTGCTTTATCTGCTGTCCGGGGACGAAACCAAAGC
GAATCGGGCGGAGGCGCTGTTCCTTCGGCGGCCGACCATCAGTGTCCAGGTACTGAACGAAGTCGCCAGCGTTTGCAGTC
GAAAATTGCGGATGCCGTGGAGCGACGTGGGGCAGTTTCTGGAGCCGATCAGGAGCTTGTGCCATGTCGTACCGGTCACG
ATCGATACGCATGACCTGGCGCGAAGGCTGGCGGAACGGCATGGCTTGTCCTTCTATGACGCGTGCATCGTCGCCGCCGC
GTCGCTCGATGGCTGTGAATACCTGTACACCGAGGACATGCACGACGGCCTGCGCGTGGACGGCGGTCCGGTGCTGCGAA
ATCCGTTCGCCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8805.04 Da
• Isoelectric Point: 8.8306

>AT129234 WP_175959113.1 NZ_CP041778:1435446-1435679 [Burkholderia sp. MS455]
MQVAKWGNSLAVRLPASVVDALELREGDDIEIVVDSPRVFAVSRKPRPDELLQRLRRFRGKLPADFKFGRDDANERD

Nucleotide

• Length: 234 bp

>AT129234 NZ_CP041778:1435446-1435679 [Burkholderia sp. MS455]
ATGCAAGTCGCAAAGTGGGGCAATAGCCTGGCCGTCCGCCTTCCCGCCAGCGTGGTCGATGCACTGGAGCTCCGCGAAGG
GGACGATATCGAAATCGTCGTCGATAGCCCGCGCGTGTTTGCCGTCAGCCGCAAGCCGAGGCCCGATGAACTTCTGCAAC
GGTTGCGGCGTTTCAGGGGCAAGCTGCCCGCCGATTTCAAGTTCGGCCGGGACGATGCGAATGAGCGGGATTGA