Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-chpS/PRK09812-MazE
Location 5232084..5232679 Replicon chromosome
Accession NZ_CP041730
Organism Chitinimonas arctica strain R3-44

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FNU76_RS23650 Protein ID WP_144280481.1
Coordinates 5232084..5232437 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag FNU76_RS23655 Protein ID WP_144280482.1
Coordinates 5232437..5232679 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNU76_RS23625 5227335..5227607 - 273 WP_144280479.1 helix-hairpin-helix domain-containing protein -
FNU76_RS23630 5227619..5228368 - 750 WP_144280802.1 transporter substrate-binding domain-containing protein -
FNU76_RS23635 5228729..5229745 + 1017 WP_144280480.1 heat-inducible transcriptional repressor HrcA -
FNU76_RS23640 5229917..5230864 + 948 WP_144280803.1 lytic murein transglycosylase B -
FNU76_RS23645 5230942..5232021 + 1080 WP_144280546.1 IS630 family transposase -
FNU76_RS23650 5232084..5232437 - 354 WP_144280481.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FNU76_RS23655 5232437..5232679 - 243 WP_144280482.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FNU76_RS23660 5232968..5234302 - 1335 WP_144280483.1 DUF1501 domain-containing protein -
FNU76_RS23665 5234346..5235860 - 1515 WP_179958272.1 DUF1800 domain-containing protein -
FNU76_RS23670 5236197..5237552 - 1356 WP_179958475.1 metalloprotease PmbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5230942..5232021 1079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-112)

Antitoxin

Antitoxin PemI-like

(1-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12595.57 Da        Isoelectric Point: 7.9536

>T129065 WP_144280481.1 NZ_CP041730:c5232437-5232084 [Chitinimonas arctica]
MAAYIPERGDLVHLQFDPAAGHEMKGPHYGFVVSPKLFNKRGLAVICPVSQGAAPAERSHGTLVSLLGAGTKVVGNIHCH
QLKSLDWQSRQAKLVERAPDFITADAMARIEAILLGE

Download         Length: 354 bp

>T129065 NZ_CP041730:c5232437-5232084 [Chitinimonas arctica]
ATGGCGGCCTACATCCCGGAGCGCGGCGACCTCGTGCATCTGCAGTTCGACCCGGCAGCGGGCCACGAAATGAAGGGGCC
GCATTATGGTTTCGTGGTCAGCCCCAAGCTGTTCAACAAACGCGGCTTGGCCGTTATTTGCCCGGTTTCGCAAGGCGCCG
CGCCGGCAGAGCGCTCACACGGCACGCTGGTATCGCTGCTGGGTGCTGGCACCAAGGTCGTCGGCAACATTCATTGCCAC
CAGCTGAAGTCGCTGGACTGGCAGTCACGGCAGGCCAAGTTGGTCGAGCGCGCGCCCGATTTCATTACCGCCGATGCGAT
GGCCCGTATTGAAGCCATCTTGCTTGGCGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8517.95 Da        Isoelectric Point: 4.9633

>AT129065 WP_144280482.1 NZ_CP041730:c5232679-5232437 [Chitinimonas arctica]
MELPIRRIGNSAGVVIPAPLLQQLKVAVGGSLNATIQGETLTLTSAKPRYKLADLLAEMPGELPRVDGWDEMPPVGREVA

Download         Length: 243 bp

>AT129065 NZ_CP041730:c5232679-5232437 [Chitinimonas arctica]
ATGGAACTACCTATCCGCAGGATCGGCAACAGCGCCGGGGTCGTTATCCCCGCGCCCTTGTTGCAGCAACTCAAGGTCGC
GGTCGGCGGCAGTCTAAACGCGACCATCCAGGGCGAAACGTTGACGCTGACCTCCGCCAAGCCCCGCTACAAGCTGGCCG
ACCTGCTGGCCGAGATGCCGGGCGAACTGCCGCGTGTCGATGGTTGGGACGAGATGCCGCCCGTTGGTCGGGAAGTGGCT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References