Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 619724..620331 Replicon chromosome
Accession NZ_CP041730
Organism Chitinimonas arctica strain R3-44

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FNU76_RS02885 Protein ID WP_144280559.1
Coordinates 619724..620035 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FNU76_RS02890 Protein ID WP_143856309.1
Coordinates 620038..620331 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNU76_RS02855 614897..615097 + 201 WP_144280558.1 general stress protein CsbD -
FNU76_RS24015 615175..615351 + 177 WP_179958322.1 hypothetical protein -
FNU76_RS02860 615496..615828 + 333 WP_143856304.1 winged helix-turn-helix domain-containing protein -
FNU76_RS02865 615859..616095 + 237 WP_143856305.1 hypothetical protein -
FNU76_RS02870 616161..616607 + 447 WP_143856306.1 hypothetical protein -
FNU76_RS02875 616641..616937 + 297 WP_143856307.1 hypothetical protein -
FNU76_RS02880 617093..619240 - 2148 WP_143856308.1 hypothetical protein -
FNU76_RS02885 619724..620035 + 312 WP_144280559.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNU76_RS02890 620038..620331 + 294 WP_143856309.1 helix-turn-helix domain-containing protein Antitoxin
FNU76_RS02895 620851..622068 + 1218 WP_143856310.1 peptidoglycan DD-metalloendopeptidase family protein -
FNU76_RS02900 622131..622574 - 444 WP_143856311.1 response regulator -
FNU76_RS02905 622749..623516 - 768 WP_143856312.1 DeoR/GlpR family DNA-binding transcription regulator -
FNU76_RS02910 623718..625259 + 1542 WP_143856313.1 glycerol-3-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(40-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-80)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11974.61 Da        Isoelectric Point: 5.7408

>T129052 WP_144280559.1 NZ_CP041730:619724-620035 [Chitinimonas arctica]
IEFIETPTFTRLVTHLLTDDEYIDLQNVLVENPERGDLIQGGGGIRKLRHASSGRGKSGGVRVIYYWIRDDEQIYMLYLY
PKSKQDKLSDRETALLREFVKDL

Download         Length: 312 bp

>T129052 NZ_CP041730:619724-620035 [Chitinimonas arctica]
ATAGAATTCATTGAAACCCCTACATTTACCCGCTTGGTCACCCACCTACTGACAGACGATGAATACATCGATCTCCAGAA
TGTCTTGGTAGAAAATCCAGAAAGGGGTGACCTGATTCAGGGCGGTGGCGGCATCCGTAAGCTGCGCCACGCCTCGTCCG
GCCGTGGAAAAAGTGGCGGTGTGCGGGTTATTTACTACTGGATTCGGGATGACGAGCAGATTTACATGCTTTATCTCTAT
CCCAAATCGAAGCAAGACAAGCTGAGCGACAGGGAAACCGCCTTGCTGCGCGAGTTTGTGAAGGACTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10943.58 Da        Isoelectric Point: 10.7279

>AT129052 WP_143856309.1 NZ_CP041730:620038-620331 [Chitinimonas arctica]
MEKIMFDELVQSLQEARSIARGDAPASRRFRVSPPDAKAIREQTGLSQSEFARLMQVSIKTLQNWEQHRRNPTGPAAALL
RIVMTAPEVVLNSQLEK

Download         Length: 294 bp

>AT129052 NZ_CP041730:620038-620331 [Chitinimonas arctica]
ATGGAAAAAATCATGTTTGACGAACTGGTGCAAAGCCTGCAAGAAGCCAGGTCCATCGCTCGCGGCGATGCCCCGGCCTC
GCGCCGATTCAGGGTTTCACCACCTGATGCCAAGGCAATACGCGAACAAACCGGCCTGTCCCAAAGCGAGTTTGCCCGTT
TAATGCAGGTGAGTATCAAGACATTGCAAAACTGGGAGCAACACCGCCGCAACCCAACGGGTCCGGCTGCTGCGTTGCTT
AGGATTGTGATGACAGCACCCGAGGTAGTACTCAACTCGCAGTTGGAAAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References