Detailed information of TA system TA128950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 1733872..1734505
• Replicon: chromosome
• Accession: NZ_CP041660
• Organism: Catenovulum sediminis strain WS1-A

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FNT16_RS06995
• Protein ID: WP_143870914.1
• Coordinates: 1733872..1734204 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2K8XYD2
• Locus tag: FNT16_RS07000
• Protein ID: WP_071979346.1
• Coordinates: 1734191..1734505 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNT16_RS06970	1728997..1729188	+	192	WP_143870911.1	phage integrase N-terminal SAM-like domain-containing protein	-
FNT16_RS06975	1729197..1730281	+	1085	Protein_1350	IS91 family transposase	-
FNT16_RS06980	1730647..1731129	+	483	WP_143870912.1	hypothetical protein	-
FNT16_RS06985	1731438..1732328	+	891	WP_143870913.1	hypothetical protein	-
FNT16_RS06990	1732408..1733070	-	663	Protein_1353	group II intron reverse transcriptase/maturase	-
FNT16_RS20365	1733133..1733306	-	174	WP_185976718.1	hypothetical protein	-
FNT16_RS06995	1733872..1734204	+	333	WP_143870914.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FNT16_RS07000	1734191..1734505	+	315	WP_071979346.1	DNA-binding transcriptional regulator	Antitoxin
FNT16_RS07010	1734911..1735222	+	312	WP_143870916.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FNT16_RS07015	1735215..1735502	+	288	WP_143870917.1	type II toxin-antitoxin system MqsA family antitoxin	-
FNT16_RS07025	1735998..1736294	+	297	WP_143870918.1	HigA family addiction module antidote protein	-
FNT16_RS07030	1736665..1737159	+	495	WP_143870919.1	ATP-binding protein	-
FNT16_RS07035	1737284..1737709	+	426	WP_143870920.1	GFA family protein	-
FNT16_RS07040	1738299..1738922	+	624	WP_143872907.1	PEP-CTERM sorting domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (11-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-92)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12800.66 Da
• Isoelectric Point: 10.2254

>T128950 WP_143870914.1 NZ_CP041660:1733872-1734204 [Catenovulum sediminis]
VKSVFVESTIFEKYRNDYLSDEAFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMADLTADQKKQLKAFMEAWRNEQS

Nucleotide

• Length: 333 bp

>T128950 NZ_CP041660:1733872-1734204 [Catenovulum sediminis]
GTGAAAAGTGTATTTGTTGAATCAACCATATTTGAAAAGTACCGAAATGATTACCTCAGTGACGAGGCGTTTCGATTGTT
CCAAGCTGAACTTATGTCGAACCCGAAGCAAGGTGACGTAATTCAAGGTACTGGTGGTTTGCGGAAGATTCGAGTAGCAA
GTAAAGGTAAGGGAAAGCGTGGTGGTTCACGTGTTATCTATTACTTCCTCGATGAAAAGCGTCGCTTCTATTTGCTGACT
ATTTACGGCAAAAATGAAATGGCAGACTTAACCGCAGATCAAAAGAAACAGTTAAAAGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11718.16 Da
• Isoelectric Point: 5.9765

>AT128950 WP_071979346.1 NZ_CP041660:1734191-1734505 [Catenovulum sediminis]
MSNRDLFAELNSALVEAKEHSEGKVTLKTHQVNDISELDISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Nucleotide

• Length: 315 bp

>AT128950 NZ_CP041660:1734191-1734505 [Catenovulum sediminis]
ATGAGCAATCGTGATCTATTTGCAGAGCTAAACTCTGCACTTGTTGAAGCTAAGGAGCATTCAGAGGGCAAAGTGACTCT
GAAAACTCATCAAGTTAATGACATCAGTGAGCTAGATATTTCACCTGATGAAATTGTTAGTATTCGTGAGCAGTTTAATA
TGTCTCGTGGTGTATTTGCTCGTTTACTGCATACATCATCACGTACATTGGAAAACTGGGAGCAGGGGCGGAGCGCACCA
AATGGACAAGCTGTTACTCTTCTAAAGCTTGTACAGCGCCACCCAGAAACTCTGTCGCACATCGCAGAGCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A2K8XYD2