Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1853434..1854265 Replicon chromosome
Accession NZ_CP041452
Organism Escherichia coli strain YPE3

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag FNP78_RS09550 Protein ID WP_000854814.1
Coordinates 1853434..1853808 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag FNP78_RS09555 Protein ID WP_001285585.1
Coordinates 1853897..1854265 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNP78_RS09510 1848830..1849996 + 1167 WP_016247321.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
FNP78_RS09515 1850115..1850588 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
FNP78_RS09520 1850786..1851844 + 1059 WP_064670363.1 FUSC family protein -
FNP78_RS09525 1852016..1852345 + 330 WP_000450409.1 DUF496 family protein -
FNP78_RS09530 1852446..1852628 - 183 WP_001016348.1 hypothetical protein -
FNP78_RS09535 1852700..1852828 + 129 Protein_1719 transposase domain-containing protein -
FNP78_RS09540 1853117..1853230 - 114 WP_001161660.1 DUF957 domain-containing protein -
FNP78_RS09545 1853243..1853437 - 195 WP_000988600.1 hypothetical protein -
FNP78_RS09550 1853434..1853808 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
FNP78_RS09555 1853897..1854265 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FNP78_RS09560 1854339..1854560 - 222 WP_000692323.1 DUF987 domain-containing protein -
FNP78_RS09565 1854623..1855099 - 477 WP_001186773.1 RadC family protein -
FNP78_RS09570 1855115..1855594 - 480 WP_000860076.1 antirestriction protein -
FNP78_RS09575 1855676..1856497 - 822 WP_064670364.1 DUF945 domain-containing protein -
FNP78_RS09585 1856718..1857128 - 411 WP_000846713.1 hypothetical protein -
FNP78_RS09590 1857144..1857827 - 684 WP_000775500.1 hypothetical protein -
FNP78_RS09595 1857963..1859033 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T128673 WP_000854814.1 NZ_CP041452:c1853808-1853434 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T128673 NZ_CP041452:c1853808-1853434 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT128673 WP_001285585.1 NZ_CP041452:c1854265-1853897 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT128673 NZ_CP041452:c1854265-1853897 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References