Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 483236..484070 | Replicon | chromosome |
| Accession | NZ_CP041359 | ||
| Organism | Escherichia coli strain U1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0H2VDB0 |
| Locus tag | E3Z32_RS03405 | Protein ID | WP_000854688.1 |
| Coordinates | 483693..484070 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0H2VAY1 |
| Locus tag | E3Z32_RS03400 | Protein ID | WP_001285596.1 |
| Coordinates | 483236..483616 (+) | Length | 127 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3Z32_RS03360 | 479521..479976 | + | 456 | WP_000581502.1 | hypothetical protein | - |
| E3Z32_RS03365 | 480055..480288 | + | 234 | WP_001119727.1 | DUF905 family protein | - |
| E3Z32_RS03375 | 480389..481207 | + | 819 | WP_001234616.1 | DUF945 domain-containing protein | - |
| E3Z32_RS03380 | 481262..481747 | + | 486 | WP_000849564.1 | antirestriction protein | - |
| E3Z32_RS03385 | 481763..482239 | + | 477 | WP_001186726.1 | RadC family protein | - |
| E3Z32_RS03390 | 482302..482523 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| E3Z32_RS03395 | 482542..483186 | + | 645 | WP_115760282.1 | antitoxin of toxin-antitoxin stability system | - |
| E3Z32_RS03400 | 483236..483616 | + | 381 | WP_001285596.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| E3Z32_RS03405 | 483693..484070 | + | 378 | WP_000854688.1 | TA system toxin CbtA family protein | Toxin |
| E3Z32_RS03410 | 484067..484555 | + | 489 | WP_000761701.1 | hypothetical protein | - |
| E3Z32_RS03415 | 484572..484769 | + | 198 | WP_000839260.1 | DUF957 domain-containing protein | - |
| E3Z32_RS03420 | 484983..486002 | + | 1020 | WP_000875213.1 | IS110 family transposase | - |
| E3Z32_RS03430 | 486286..487131 | + | 846 | WP_001280441.1 | DUF4942 domain-containing protein | - |
| E3Z32_RS03435 | 487200..487595 | + | 396 | WP_000208383.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| E3Z32_RS03440 | 487588..488522 | + | 935 | Protein_467 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsT / kpsM / gspM | 483236..508830 | 25594 | |
| - | flank | IS/Tn | - | - | 484983..486002 | 1019 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14014.01 Da Isoelectric Point: 8.5221
>T128174 WP_000854688.1 NZ_CP041359:483693-484070 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T128174 NZ_CP041359:483693-484070 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 127 a.a. Molecular weight: 13897.70 Da Isoelectric Point: 4.7959
>AT128174 WP_001285596.1 NZ_CP041359:483236-483616 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
Download Length: 381 bp
>AT128174 NZ_CP041359:483236-483616 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCGCCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCGCCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2VDB0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2VAY1 |