Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1853432..1854263 Replicon chromosome
Accession NZ_CP041284
Organism Escherichia coli strain 54

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag FK536_RS08845 Protein ID WP_000854814.1
Coordinates 1853432..1853806 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag FK536_RS08850 Protein ID WP_001285585.1
Coordinates 1853895..1854263 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FK536_RS08805 1848828..1849994 + 1167 WP_016247321.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
FK536_RS08810 1850113..1850586 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
FK536_RS08815 1850784..1851842 + 1059 WP_064670363.1 FUSC family protein -
FK536_RS08820 1852014..1852343 + 330 WP_000450409.1 DUF496 family protein -
FK536_RS08825 1852444..1852626 - 183 WP_001016348.1 hypothetical protein -
FK536_RS08830 1852698..1852826 + 129 Protein_1719 transposase domain-containing protein -
FK536_RS08835 1853115..1853228 - 114 WP_001161660.1 DUF957 domain-containing protein -
FK536_RS08840 1853241..1853435 - 195 WP_000988600.1 hypothetical protein -
FK536_RS08845 1853432..1853806 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
FK536_RS08850 1853895..1854263 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FK536_RS08855 1854337..1854558 - 222 WP_000692323.1 DUF987 domain-containing protein -
FK536_RS08860 1854621..1855097 - 477 WP_001186773.1 RadC family protein -
FK536_RS08865 1855113..1855592 - 480 WP_000860076.1 antirestriction protein -
FK536_RS08870 1855674..1856495 - 822 WP_064670364.1 DUF945 domain-containing protein -
FK536_RS08875 1856716..1857126 - 411 WP_000846713.1 hypothetical protein -
FK536_RS08880 1857142..1857825 - 684 WP_000775500.1 hypothetical protein -
FK536_RS08885 1857961..1859031 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T127917 WP_000854814.1 NZ_CP041284:c1853806-1853432 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T127917 NZ_CP041284:c1853806-1853432 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT127917 WP_001285585.1 NZ_CP041284:c1854263-1853895 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT127917 NZ_CP041284:c1854263-1853895 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References