Detailed information of TA system TA127844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 116495..117152
• Replicon: plasmid pCFSAN074384_1
• Accession: NZ_CP041209
• Organism: Salmonella enterica subsp. enterica serovar Newport strain SAP18-8729

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: D2X89_RS24220
• Protein ID: WP_000270043.1
• Coordinates: 116802..117152 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: D2X89_RS24215
• Protein ID: WP_000124640.1
• Coordinates: 116495..116797 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D2X89_RS24165	112120..112548	+	429	WP_000591074.1	hypothetical protein	-
D2X89_RS24170	112605..112964	+	360	WP_000422768.1	hypothetical protein	-
D2X89_RS24175	112964..113410	+	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
D2X89_RS24180	113407..113925	+	519	WP_000210756.1	nitrite reductase	-
D2X89_RS24185	113925..114155	+	231	WP_000972663.1	hypothetical protein	-
D2X89_RS24190	114142..114999	+	858	WP_001167032.1	hypothetical protein	-
D2X89_RS24200	115230..115757	+	528	WP_001236377.1	thermonuclease family protein	-
D2X89_RS24205	115815..116087	+	273	WP_001043047.1	HU family DNA-binding protein	-
D2X89_RS24210	116175..116468	+	294	WP_001239997.1	chromosome segregation protein ParM	-
D2X89_RS24215	116495..116797	-	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
D2X89_RS24220	116802..117152	-	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D2X89_RS24225	117315..117863	+	549	WP_001061574.1	transcriptional regulator	-
D2X89_RS24235	118204..118398	+	195	WP_000343597.1	hypothetical protein	-
D2X89_RS24240	118409..118780	+	372	WP_000516916.1	hypothetical protein	-
D2X89_RS24245	118773..119243	+	471	WP_001281821.1	hypothetical protein	-
D2X89_RS24250	119258..119593	-	336	WP_000683476.1	hypothetical protein	-
D2X89_RS24255	119690..120178	+	489	WP_001273096.1	DUF1643 domain-containing protein	-
D2X89_RS24260	120181..120678	+	498	WP_000062185.1	hypothetical protein	-
D2X89_RS24270	120893..121597	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
D2X89_RS24275	121662..121841	-	180	Protein_134	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..158212	158212

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 17237.68 Da
• Isoelectric Point: 5.5500

>T127844 WP_000270043.1 NZ_CP041209:c117152-116802 [Salmonella enterica subsp. enterica serovar Newport]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 351 bp

>T127844 NZ_CP041209:c117152-116802 [Salmonella enterica subsp. enterica serovar Newport]
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Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 14882.85 Da
• Isoelectric Point: 5.5500

>AT127844 WP_000124640.1 NZ_CP041209:c116797-116495 [Salmonella enterica subsp. enterica serovar Newport]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 303 bp

>AT127844 NZ_CP041209:c116797-116495 [Salmonella enterica subsp. enterica serovar Newport]
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Structures

Toxin

• AlphaFold DB: A0A7G8AFB9