Detailed information of TA system TA127760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 7364..7889
• Replicon: plasmid p12367B
• Accession: NZ_CP041178
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain SJTUF12367v2

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: FKO11_RS23760
• Protein ID: WP_001159863.1
• Coordinates: 7364..7669 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: FKO11_RS23765
• Protein ID: WP_000813641.1
• Coordinates: 7671..7889 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FKO11_RS23725	2743..3303	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
FKO11_RS24215	3459..3746	+	288	WP_071530243.1	hypothetical protein	-
FKO11_RS23730	4023..4508	-	486	WP_000905606.1	membrane protein	-
FKO11_RS23735	4502..5011	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
FKO11_RS23740	5015..5728	-	714	WP_121212594.1	EAL domain-containing protein	-
FKO11_RS23745	5737..6519	-	783	WP_000082169.1	site-specific integrase	-
FKO11_RS23750	6554..7075	-	522	WP_000198608.1	hypothetical protein	-
FKO11_RS23755	7072..7362	-	291	WP_001266176.1	hypothetical protein	-
FKO11_RS23760	7364..7669	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
FKO11_RS23765	7671..7889	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
FKO11_RS23770	8565..9086	+	522	WP_077681952.1	hypothetical protein	-
FKO11_RS24300	9130..9558	-	429	Protein_15	hypothetical protein	-
FKO11_RS23780	9570..9865	+	296	Protein_16	cytoplasmic protein	-
FKO11_RS23785	10359..11348	+	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
FKO11_RS23790	11675..11836	-	162	WP_015059604.1	hypothetical protein	-
FKO11_RS23795	11889..12275	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59372	59372

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T127760 WP_001159863.1 NZ_CP041178:c7669-7364 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T127760 NZ_CP041178:c7669-7364 [Salmonella enterica subsp. enterica serovar Enteritidis]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT127760 WP_000813641.1 NZ_CP041178:c7889-7671 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT127760 NZ_CP041178:c7889-7671 [Salmonella enterica subsp. enterica serovar Enteritidis]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6