Detailed information of TA system TA127674

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4510618..4511090
• Replicon: chromosome
• Accession: NZ_CP041125
• Organism: Serratia marcescens strain WVU-004

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D428
• Locus tag: FG169_RS21750
• Protein ID: WP_049208401.1
• Coordinates: 4510618..4510893 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FG169_RS21755
• Protein ID: WP_141960248.1
• Coordinates: 4510899..4511090 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG169_RS21725	4505938..4507218	-	1281	WP_055311947.1	polysaccharide deacetylase family protein	-
FG169_RS21730	4507396..4508166	-	771	WP_004937535.1	ABC transporter permease	-
FG169_RS21735	4508163..4509086	-	924	WP_033644695.1	ABC transporter ATP-binding protein	-
FG169_RS21740	4509297..4509953	+	657	WP_049200096.1	carbonate dehydratase	-
FG169_RS21745	4509991..4510527	-	537	WP_048234659.1	hypoxanthine phosphoribosyltransferase	-
FG169_RS21750	4510618..4510893	-	276	WP_049208401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FG169_RS21755	4510899..4511090	-	192	WP_141960248.1	stability determinant	Antitoxin
FG169_RS21760	4511196..4512896	-	1701	WP_141960250.1	multicopper oxidase CueO	-
FG169_RS21765	4513115..4513462	+	348	WP_004937515.1	YacC family pilotin-like protein	-
FG169_RS21770	4513587..4514450	+	864	WP_070913726.1	polyamine aminopropyltransferase	-
FG169_RS21775	4514478..4515272	+	795	WP_049200100.1	adenosylmethionine decarboxylase	-
FG169_RS21780	4515305..4515667	-	363	WP_004937507.1	protein YacL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10410.13 Da
• Isoelectric Point: 6.8785

>T127674 WP_049208401.1 NZ_CP041125:c4510893-4510618 [Serratia marcescens]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VSVLHARQEYP

Nucleotide

• Length: 276 bp

>T127674 NZ_CP041125:c4510893-4510618 [Serratia marcescens]
ATGTTAACCGTCAAATGGACTGACGAAGCAAAAACGGGTTTATATACGCTGCTGGCTTTTATCGCTGAGCGAAATCCACT
TGCCGCAGAGGCTTTGTTGCAACGCATTGAAGAGTCGGTTATCCCGTTAGCGGAACATCCTTATCTATTCAGGCCAGGCA
GGGTGAACGGGACTCGTGAAATGGTTGTTCATCCTAATTACATTGTGGTTTACCGCGTGCTGGCTGCACATATTGAAATA
GTGAGTGTCCTGCACGCTCGTCAGGAATACCCTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7161.95 Da
• Isoelectric Point: 5.6492

>AT127674 WP_141960248.1 NZ_CP041125:c4511090-4510899 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDRWFRSTVESSISSDSPRIPHDEVMAGARHIIEQAKAKRKSA

Nucleotide

• Length: 192 bp

>AT127674 NZ_CP041125:c4511090-4510899 [Serratia marcescens]
ATGCCGACAAAATTGGATCCCATCGTTTCTGAGTTTGAGACTCAAGAGCAGGCTGATAGCTACGATCGTTGGTTCAGAAG
CACCGTGGAATCTTCCATCAGTAGCGACTCCCCCCGTATTCCCCATGACGAAGTCATGGCCGGCGCTCGTCACATTATCG
AGCAGGCGAAAGCCAAAAGAAAATCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D428