Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3882868..3883430 Replicon chromosome
Accession NZ_CP041125
Organism Serratia marcescens strain WVU-004

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag FG169_RS18775 Protein ID WP_025303801.1
Coordinates 3882868..3883224 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag FG169_RS18780 Protein ID WP_004936539.1
Coordinates 3883221..3883430 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG169_RS18755 3878603..3879400 - 798 WP_141959878.1 energy transducer TonB -
FG169_RS18760 3879503..3880342 - 840 WP_047571061.1 ChaN family lipoprotein -
FG169_RS18765 3880520..3881929 + 1410 WP_047730133.1 S-methylmethionine permease -
FG169_RS18770 3881919..3882857 + 939 WP_141959880.1 homocysteine S-methyltransferase -
FG169_RS18775 3882868..3883224 - 357 WP_025303801.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FG169_RS18780 3883221..3883430 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FG169_RS18785 3883540..3885819 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
FG169_RS18790 3886034..3886243 - 210 WP_141960708.1 hypothetical protein -
FG169_RS18795 3886188..3886568 - 381 WP_084827301.1 DUF2570 family protein -
FG169_RS18800 3886565..3886966 - 402 WP_019453868.1 M15 family metallopeptidase -
FG169_RS18805 3886956..3887282 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13163.93 Da        Isoelectric Point: 4.9139

>T127670 WP_025303801.1 NZ_CP041125:c3883224-3882868 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T127670 NZ_CP041125:c3883224-3882868 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAGTTCAATGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAAGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTACGAGAACGTCACAGACGTTTACCGCTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCTGCTGAACACTTACGCCGGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT127670 WP_004936539.1 NZ_CP041125:c3883430-3883221 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT127670 NZ_CP041125:c3883430-3883221 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAAGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References