Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 167011..167536 Replicon plasmid SA20143792 strain 14[5]12:i:-
Accession NZ_CP041027
Organism Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain SA20143792

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag FI669_RS25720 Protein ID WP_001159863.1
Coordinates 167231..167536 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag FI669_RS25715 Protein ID WP_000813641.1
Coordinates 167011..167229 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FI669_RS25700 164450..164638 + 189 WP_000957857.1 hypothetical protein -
FI669_RS25705 164648..165835 + 1188 Protein_197 IS91 family transposase -
FI669_RS25710 166008..166328 - 321 Protein_198 hypothetical protein -
FI669_RS25715 167011..167229 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
FI669_RS25720 167231..167536 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
FI669_RS25725 167538..167828 + 291 WP_001266176.1 hypothetical protein -
FI669_RS25730 167825..168346 + 522 WP_000198608.1 hypothetical protein -
FI669_RS25735 168381..169163 + 783 WP_000082169.1 site-specific integrase -
FI669_RS25740 169172..169885 + 714 Protein_204 EAL domain-containing protein -
FI669_RS25750 169889..170398 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
FI669_RS25755 170392..170877 + 486 WP_000905606.1 membrane protein -
FI669_RS25760 171154..171441 - 288 WP_071530243.1 hypothetical protein -
FI669_RS25765 171597..172157 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..190723 190723


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T127455 WP_001159863.1 NZ_CP041027:167231-167536 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T127455 NZ_CP041027:167231-167536 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT127455 WP_000813641.1 NZ_CP041027:167011-167229 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT127455 NZ_CP041027:167011-167229 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References