Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1233208..1234026 Replicon chromosome
Accession NZ_CP041002
Organism Escherichia coli strain FDAARGOS_772

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0Y102
Locus tag FIU16_RS06555 Protein ID WP_000771609.1
Coordinates 1233652..1234026 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0Y470
Locus tag FIU16_RS06550 Protein ID WP_001285568.1
Coordinates 1233208..1233561 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU16_RS06510 1228481..1228831 + 351 WP_000624688.1 IS66 family insertion sequence element accessory protein TnpB -
FIU16_RS06515 1228862..1230475 + 1614 WP_000080172.1 IS66-like element ISEc43 family transposase -
FIU16_RS06525 1230723..1231544 + 822 WP_001241709.1 DUF945 domain-containing protein -
FIU16_RS06530 1231544..1231789 + 246 WP_001164966.1 hypothetical protein -
FIU16_RS06535 1231883..1232356 + 474 WP_000855049.1 antirestriction protein -
FIU16_RS06540 1232372..1232848 + 477 WP_001186756.1 RadC family protein -
FIU16_RS06545 1232911..1233132 + 222 WP_000692357.1 DUF987 domain-containing protein -
FIU16_RS06550 1233208..1233561 + 354 WP_001285568.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FIU16_RS06555 1233652..1234026 + 375 WP_000771609.1 TA system toxin CbtA family protein Toxin
FIU16_RS06560 1234023..1234514 + 492 WP_000976860.1 hypothetical protein -
FIU16_RS06565 1234526..1234723 + 198 WP_000839270.1 DUF957 domain-containing protein -
FIU16_RS06570 1234808..1235650 + 843 WP_001274560.1 DUF4942 domain-containing protein -
FIU16_RS06580 1236121..1237059 + 939 WP_000351313.1 glyoxylate/hydroxypyruvate reductase GhrA -
FIU16_RS06585 1237114..1237851 + 738 WP_000283664.1 zinc-binding phosphatase -
FIU16_RS06590 1237875..1238429 + 555 WP_001001902.1 molecular chaperone YcdY -
FIU16_RS06595 1238531..1239022 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14006.09 Da        Isoelectric Point: 7.2652

>T127359 WP_000771609.1 NZ_CP041002:1233652-1234026 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T127359 NZ_CP041002:1233652-1234026 [Escherichia coli]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13064.82 Da        Isoelectric Point: 5.9541

>AT127359 WP_001285568.1 NZ_CP041002:1233208-1233561 [Escherichia coli]
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK

Download         Length: 354 bp

>AT127359 NZ_CP041002:1233208-1233561 [Escherichia coli]
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y102

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y470

References