Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 144208..144728 Replicon chromosome
Accession NZ_CP040872
Organism Agromyces laixinhei strain HY052

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag FHG54_RS00725 Protein ID WP_139415449.1
Coordinates 144438..144728 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag FHG54_RS00720 Protein ID WP_139415448.1
Coordinates 144208..144441 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHG54_RS00695 139808..140371 + 564 WP_139418218.1 isopentenyl-diphosphate Delta-isomerase -
FHG54_RS00700 140504..141445 - 942 WP_139415445.1 site-specific DNA-methyltransferase -
FHG54_RS00705 141566..141886 - 321 WP_139415446.1 hypothetical protein -
FHG54_RS00710 142047..143096 - 1050 WP_139415447.1 lipoate--protein ligase family protein -
FHG54_RS16455 143176..143580 + 405 WP_210415450.1 histidine phosphatase family protein -
FHG54_RS16460 143570..143860 + 291 WP_210415518.1 histidine phosphatase family protein -
FHG54_RS00720 144208..144441 + 234 WP_139415448.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FHG54_RS00725 144438..144728 + 291 WP_139415449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FHG54_RS00730 144790..145560 - 771 WP_168197046.1 helix-turn-helix transcriptional regulator -
FHG54_RS00735 145680..146474 + 795 WP_139415451.1 methyltransferase domain-containing protein -
FHG54_RS00740 146540..147145 - 606 WP_210415451.1 methyltransferase domain-containing protein -
FHG54_RS00745 147239..147550 + 312 WP_139415453.1 pyrophosphatase -
FHG54_RS00750 147722..148381 - 660 WP_139415454.1 TetR/AcrR family transcriptional regulator -
FHG54_RS00755 148485..148958 + 474 WP_139418219.1 ester cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11306.63 Da        Isoelectric Point: 7.2763

>T127140 WP_139415449.1 NZ_CP040872:144438-144728 [Agromyces laixinhei]
VKGYRLTPAAQRDLSSIWNFTQERWDANQAETYVTEIRAAIERIADDPRRGRNCDEIREGYRRYSIGSHLLFYVESADGV
DVIRILHQRMDPTRHL

Download         Length: 291 bp

>T127140 NZ_CP040872:144438-144728 [Agromyces laixinhei]
GTGAAGGGCTACCGGCTTACACCGGCGGCGCAACGAGACCTCTCCTCGATCTGGAACTTCACCCAGGAGCGCTGGGACGC
CAATCAGGCGGAGACCTACGTGACTGAGATCAGAGCAGCGATCGAGCGCATCGCCGACGACCCCAGGCGCGGACGCAACT
GCGATGAGATCCGCGAGGGATACCGTCGGTACAGCATCGGCAGCCACCTGCTGTTCTACGTCGAGAGCGCCGACGGCGTG
GATGTAATCCGGATCCTGCATCAGCGCATGGATCCGACACGACACCTGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8374.22 Da        Isoelectric Point: 4.5515

>AT127140 WP_139415448.1 NZ_CP040872:144208-144441 [Agromyces laixinhei]
MAHNTSISLDDHFSDFLSREVSSGRFRSSSEVVRAGLRLLEDQETQLAALRAALVAGENSGEPEAFDFDAFIAAKKS

Download         Length: 234 bp

>AT127140 NZ_CP040872:144208-144441 [Agromyces laixinhei]
ATGGCTCATAATACCTCGATCAGCCTGGACGACCACTTCTCGGACTTCCTCTCGCGAGAGGTCTCGTCGGGGCGTTTCCG
ATCCAGCAGCGAGGTCGTCCGCGCCGGCCTCCGGCTGCTCGAGGATCAGGAGACGCAACTTGCCGCTCTGCGTGCTGCCC
TCGTCGCCGGCGAGAATAGCGGCGAGCCAGAGGCGTTCGACTTCGACGCCTTCATCGCAGCGAAGAAGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References