Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3759055..3759313 Replicon chromosome
Accession NZ_CP040805
Organism Escherichia fergusonii strain EFCF056

Toxin (Protein)


Gene name hokC Uniprot ID -
Locus tag D8Z79_RS18190 Protein ID WP_077626863.1
Coordinates 3759104..3759313 (+) Length 70 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3759055..3759112 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z79_RS18165 3754858..3755799 - 942 WP_125401164.1 bifunctional riboflavin kinase/FAD synthetase -
D8Z79_RS18170 3755807..3756025 - 219 WP_046076805.1 DUF2575 family protein -
D8Z79_RS18175 3756128..3756391 + 264 WP_001274021.1 30S ribosomal protein S20 -
D8Z79_RS18180 3756487..3757386 - 900 WP_000019050.1 transcriptional activator NhaR -
D8Z79_RS18185 3757454..3758620 - 1167 WP_046076806.1 Na+/H+ antiporter NhaA -
- 3759055..3759112 - 58 - - Antitoxin
D8Z79_RS18190 3759104..3759313 + 210 WP_077626863.1 type I toxin-antitoxin system Hok family toxin Toxin
D8Z79_RS18195 3759418..3760548 - 1131 WP_001118464.1 molecular chaperone DnaJ -
D8Z79_RS18200 3760637..3762553 - 1917 WP_000516135.1 molecular chaperone DnaK -
D8Z79_RS18205 3763061..3763627 + 567 WP_000528529.1 acetate uptake transporter -
D8Z79_RS18210 3763661..3764248 - 588 WP_002431696.1 molybdopterin adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(25-66)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7728.25 Da        Isoelectric Point: 9.3680

>T127013 WP_077626863.1 NZ_CP040805:3759104-3759313 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICVTAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 210 bp

>T127013 NZ_CP040805:3759104-3759313 [Escherichia fergusonii]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
AGTCGCTCTGATCGTCATCTGTGTCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT127013 NZ_CP040805:c3759112-3759055 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References