Detailed information of TA system TA126993

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 150453..150711
• Replicon: chromosome
• Accession: NZ_CP040805
• Organism: Escherichia fergusonii strain EFCF056

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: D8Z79_RS00705
• Protein ID: WP_001135723.1
• Coordinates: 150559..150711 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	150453..150508 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8Z79_RS00680	145668..145967	+	300	WP_024256552.1	YsaB family lipoprotein	-
D8Z79_RS00685	146063..146974	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
D8Z79_RS00690	146984..149053	+	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
D8Z79_RS00695	149122..149502	+	381	WP_139535865.1	hypothetical protein	-
D8Z79_RS00700	149437..150134	-	698	Protein_137	IS1 family transposase	-
-	150453..150508	-	56	-	-	Antitoxin
D8Z79_RS00705	150559..150711	+	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
D8Z79_RS00710	150870..151241	+	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
D8Z79_RS00715	151295..151507	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
D8Z79_RS00720	151789..152079	-	291	WP_000455800.1	HTH-type transcriptional regulator	-
D8Z79_RS00725	152329..153699	-	1371	WP_125400772.1	MFS transporter	-
D8Z79_RS00735	154137..154847	+	711	WP_000190514.1	DUF3053 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T126993 WP_001135723.1 NZ_CP040805:150559-150711 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T126993 NZ_CP040805:150559-150711 [Escherichia fergusonii]
ATGCCGCAGAAATACGGATTACTTTCGTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGAGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAAATTGAAAGAGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT126993 NZ_CP040805:c150508-150453 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin