Detailed information of TA system TA126949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 28679..29367
• Replicon: plasmid unnamed2
• Accession: NZ_CP040762
• Organism: Paracoccus liaowanqingii strain 2251

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E4191_RS18750
• Protein ID: WP_139616102.1
• Coordinates: 28951..29367 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: E4191_RS18745
• Protein ID: WP_136887690.1
• Coordinates: 28679..28942 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4191_RS18720	24210..25460	-	1251	WP_139616100.1	IS256 family transposase	-
E4191_RS18725	26452..26637	+	186	WP_139615953.1	hypothetical protein	-
E4191_RS18730	27326..27673	+	348	WP_139615954.1	DUF883 family protein	-
E4191_RS18735	27745..28179	+	435	WP_139615955.1	acyl-CoA thioesterase	-
E4191_RS18740	28224..28376	-	153	WP_139616101.1	glutaminase	-
E4191_RS18745	28679..28942	+	264	WP_136887690.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E4191_RS18750	28951..29367	+	417	WP_139616102.1	type II toxin-antitoxin system VapC family toxin	Toxin
E4191_RS18755	29564..29827	+	264	WP_139615956.1	WGR domain-containing protein	-
E4191_RS18760	29824..30309	+	486	WP_139615957.1	YecA family protein	-
E4191_RS18765	30447..30530	+	84	Protein_33	SEC-C domain-containing protein	-
E4191_RS18780	30778..31218	-	441	WP_139615958.1	type II toxin-antitoxin system VapC family toxin	-
E4191_RS18785	31203..31448	-	246	WP_139615959.1	type II toxin-antitoxin system VapB family antitoxin	-
E4191_RS18790	32683..33534	+	852	WP_139615960.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..244326	244326
	-	flank	IS/Tn	-	-	24210..25511	1301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-120)

Antitoxin

• SpoVT-AbrB domain (16-53)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14432.47 Da
• Isoelectric Point: 4.4697

>T126949 WP_139616102.1 NZ_CP040762:28951-29367 [Paracoccus liaowanqingii]
MLDTNVISDLLRNPGGPAAKRIAEVGPDAICVSIITAAELRYGCAKKGSAKLLAHVEAILESVQILAFDVPADTEYGGIR
AELEAAGRPIGPNDLLIAAHACATGAILVTGNTGEFTRVRGLRVENWIADIAPQETDD

Nucleotide

• Length: 417 bp

>T126949 NZ_CP040762:28951-29367 [Paracoccus liaowanqingii]
ATGCTGGACACGAACGTAATCTCTGATCTGCTGCGCAATCCCGGTGGTCCTGCGGCAAAGCGGATCGCCGAGGTCGGGCC
TGATGCGATCTGCGTCAGCATCATCACTGCCGCCGAGCTTCGATACGGTTGCGCGAAGAAGGGATCGGCTAAGCTTCTTG
CGCATGTCGAGGCGATCCTAGAAAGTGTGCAGATCCTGGCGTTCGATGTTCCTGCCGACACCGAATATGGGGGCATTCGC
GCCGAGCTCGAGGCTGCGGGTAGGCCCATCGGTCCAAACGATCTGCTGATCGCGGCGCATGCCTGTGCGACCGGGGCAAT
CCTCGTCACGGGCAATACGGGAGAGTTTACGCGCGTGCGCGGCTTGCGGGTTGAAAACTGGATCGCTGACATCGCGCCTC
AAGAAACCGATGACTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9934.42 Da
• Isoelectric Point: 5.1070

>AT126949 WP_136887690.1 NZ_CP040762:28679-28942 [Paracoccus liaowanqingii]
MSQLQPLSEPREVKLFRNNKSQAVRIPADFEMPGDRVNIYRDGDRLIIAPVRRKNILEVLARLDPLGPEDQFPDVDGTLL
PARNIDL

Nucleotide

• Length: 264 bp

>AT126949 NZ_CP040762:28679-28942 [Paracoccus liaowanqingii]
ATGTCGCAACTGCAGCCGTTATCAGAGCCCCGCGAGGTGAAGCTCTTTCGCAACAACAAAAGCCAGGCTGTCCGCATCCC
AGCTGACTTCGAAATGCCCGGGGATCGGGTAAATATTTACCGGGACGGTGATCGGCTGATTATTGCCCCGGTTCGCCGGA
AAAACATTCTGGAGGTGTTGGCCCGGCTGGACCCGCTCGGGCCAGAGGATCAGTTTCCTGATGTGGACGGAACGCTGCTT
CCAGCAAGGAACATTGATCTGTGA