Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1606273..1606925 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag FF956_RS07490 Protein ID WP_003412752.1
Coordinates 1606273..1606698 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag FF956_RS07495 Protein ID WP_003412749.1
Coordinates 1606704..1606925 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS07465 (FF956_07815) 1601278..1601835 + 558 WP_003412768.1 MaoC family dehydratase -
FF956_RS07470 (FF956_07820) 1601832..1602653 + 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
FF956_RS07475 (FF956_07825) 1602912..1604015 + 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
FF956_RS07480 (FF956_07830) 1604026..1605072 + 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
FF956_RS07485 (FF956_07835) 1605069..1606250 + 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
FF956_RS07490 (FF956_07840) 1606273..1606698 - 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
FF956_RS07495 (FF956_07845) 1606704..1606925 - 222 WP_003412749.1 antitoxin Antitoxin
FF956_RS07500 (FF956_07850) 1606978..1607730 - 753 WP_003901416.1 hypothetical protein -
FF956_RS07505 (FF956_07855) 1607720..1608343 - 624 WP_003900858.1 TIGR00725 family protein -
FF956_RS07510 (FF956_07860) 1608479..1608685 + 207 WP_003899347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T126756 WP_003412752.1 NZ_CP040692:c1606698-1606273 [Mycobacterium tuberculosis complex sp. N0157]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T126756 NZ_CP040692:c1606698-1606273 [Mycobacterium tuberculosis complex sp. N0157]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT126756 WP_003412749.1 NZ_CP040692:c1606925-1606704 [Mycobacterium tuberculosis complex sp. N0157]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT126756 NZ_CP040692:c1606925-1606704 [Mycobacterium tuberculosis complex sp. N0157]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References