Detailed information of TA system TA126691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 752090..752723
• Replicon: chromosome
• Accession: NZ_CP040691
• Organism: Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQD6
• Locus tag: FF955_RS03455
• Protein ID: WP_003403365.1
• Coordinates: 752090..752473 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ56
• Locus tag: FF955_RS03460
• Protein ID: WP_003403368.1
• Coordinates: 752568..752723 (-)
• Length: 52 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF955_RS03430 (FF955_03500)	747382..747918	+	537	WP_003403341.1	50S ribosomal protein L10	-
FF955_RS03435 (FF955_03505)	747955..748347	+	393	WP_003403353.1	50S ribosomal protein L7/L12	-
FF955_RS03440 (FF955_03510)	748340..749035	-	696	WP_003403355.1	TetR/AcrR family transcriptional regulator	-
FF955_RS03445 (FF955_03515)	749106..750611	+	1506	WP_003403360.1	carotenoid cleavage oxygenase	-
FF955_RS03450 (FF955_03520)	750692..751702	+	1011	WP_003911248.1	ABC transporter ATP-binding protein	-
FF955_RS03455 (FF955_03525)	752090..752473	-	384	WP_003403365.1	ribonuclease VapC6	Toxin
FF955_RS03460 (FF955_03530)	752568..752723	-	156	WP_003403368.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FF955_RS03465 (FF955_03535)	752799..753515	-	717	WP_003403371.1	CPBP family intramembrane metalloprotease	-
FF955_RS03470 (FF955_03540)	753791..754099	-	309	WP_003403376.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FF955_RS03475 (FF955_03545)	754086..754331	-	246	WP_003403381.1	ribbon-helix-helix protein, CopG family	-
FF955_RS03480 (FF955_03550)	754441..754878	-	438	WP_003403386.1	type II toxin-antitoxin system VapC family toxin	-
FF955_RS03485 (FF955_03555)	754875..755129	-	255	WP_003911263.1	antitoxin VapB7	-
FF955_RS03490 (FF955_03560)	755243..757606	+	2364	WP_003901895.1	arylsulfatase AtsD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-44)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 13959.73 Da
• Isoelectric Point: 6.0803

>T126691 WP_003403365.1 NZ_CP040691:c752473-752090 [Mycobacterium tuberculosis complex sp. N0155]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Nucleotide

• Length: 384 bp

>T126691 NZ_CP040691:c752473-752090 [Mycobacterium tuberculosis complex sp. N0155]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 52 a.a.
• Molecular weight: 5872.72 Da
• Isoelectric Point: 5.7734

>AT126691 WP_003403368.1 NZ_CP040691:c752723-752568 [Mycobacterium tuberculosis complex sp. N0155]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Nucleotide

• Length: 156 bp

>AT126691 NZ_CP040691:c752723-752568 [Mycobacterium tuberculosis complex sp. N0155]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Toxin

• AlphaFold DB: G0TQD6

Antitoxin

• AlphaFold DB: A0A7U4BSF8