Detailed information of TA system TA125872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 4847254..4847894
• Replicon: chromosome
• Accession: NZ_CP040506
• Organism: Hungatella hathewayi WAL-18680

Toxin (Protein)

• Gene name: higB
• Uniprot ID: G5ICH3
• Locus tag: FFD75_RS22110
• Protein ID: WP_006779185.1
• Coordinates: 4847254..4847616 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FFD75_RS22115
• Protein ID: WP_006779186.1
• Coordinates: 4847619..4847894 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFD75_RS22100	4842860..4843693	+	834	WP_006779183.1	carbohydrate ABC transporter permease	-
FFD75_RS22105	4843864..4846953	+	3090	WP_006779184.1	DUF4981 domain-containing protein	-
FFD75_RS22110	4847254..4847616	+	363	WP_006779185.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FFD75_RS22115	4847619..4847894	+	276	WP_006779186.1	helix-turn-helix transcriptional regulator	Antitoxin
FFD75_RS25805	4848040..4848210	+	171	WP_006779187.1	hypothetical protein	-
FFD75_RS22120	4848197..4848535	+	339	WP_006779188.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FFD75_RS22125	4848728..4849621	+	894	WP_006779189.1	AraC family transcriptional regulator	-
FFD75_RS22130	4849614..4850561	+	948	WP_006779190.1	DMT family transporter	-
FFD75_RS22135	4850789..4851052	+	264	WP_006779191.1	hypothetical protein	-
FFD75_RS22140	4851197..4851907	+	711	WP_006779192.1	hypothetical protein	-
FFD75_RS22145	4851931..4852548	+	618	WP_198138525.1	CatB-related O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (39-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-83)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13793.92 Da
• Isoelectric Point: 9.8529

>T125872 WP_006779185.1 NZ_CP040506:4847254-4847616 [Hungatella hathewayi WAL-18680]
MYNIIFYEGKDGSSGVADLLKELREKADTSKDAKINFCKIVAYLDLLSERGTAMGEPVLKYLGDGIWELRPLRNRILFAS
YQEDGFIILHHFIKKTQKTPAREIRRAKANLRDFEKRNGG

Nucleotide

• Length: 363 bp

>T125872 NZ_CP040506:4847254-4847616 [Hungatella hathewayi WAL-18680]
ATGTATAATATCATTTTTTACGAAGGAAAAGACGGAAGTAGTGGTGTTGCTGATTTATTGAAGGAATTGAGAGAAAAAGC
GGATACCTCGAAGGATGCGAAGATTAATTTTTGTAAGATAGTCGCGTATCTTGATTTGTTATCAGAGAGAGGGACCGCTA
TGGGAGAGCCGGTTTTAAAGTATTTGGGAGATGGCATCTGGGAATTGAGACCGCTTCGGAACAGGATTCTGTTTGCGTCT
TACCAGGAGGACGGTTTTATTATTCTGCATCATTTTATAAAAAAGACGCAGAAGACACCGGCCAGGGAGATTCGAAGAGC
CAAGGCAAATTTAAGAGATTTTGAGAAGAGGAATGGAGGATAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10514.35 Da
• Isoelectric Point: 5.7698

>AT125872 WP_006779186.1 NZ_CP040506:4847619-4847894 [Hungatella hathewayi WAL-18680]
MAKNWIELRKELDITPEEEAVIEMEKELIETLVKIREEEGLTQAELARKCHVKQPVIARLENGVHSPQVNSLLKILVPLG
YTLRVTPMEKR

Nucleotide

• Length: 276 bp

>AT125872 NZ_CP040506:4847619-4847894 [Hungatella hathewayi WAL-18680]
ATGGCTAAGAATTGGATAGAGTTGAGGAAAGAACTGGATATCACTCCGGAAGAGGAGGCTGTCATTGAGATGGAGAAGGA
ATTGATTGAAACGCTGGTGAAGATTCGGGAGGAAGAGGGACTCACCCAGGCGGAGCTTGCCAGGAAATGCCATGTGAAGC
AGCCGGTGATCGCGCGGCTGGAAAATGGAGTCCATTCTCCTCAGGTGAACAGTCTGTTAAAGATACTGGTCCCGCTGGGA
TATACGCTGCGGGTGACGCCGATGGAGAAGCGGTGA

Structures

Toxin

• AlphaFold DB: G5ICH3