Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3051383..3052184 Replicon chromosome
Accession NZ_CP040456
Organism Escherichia coli strain UPEC132

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag FE252_RS16505 Protein ID WP_000854739.1
Coordinates 3051383..3051763 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag FE252_RS16510 Protein ID WP_001285482.1
Coordinates 3051810..3052184 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE252_RS16470 3046975..3047529 - 555 WP_001001921.1 molecular chaperone YcdY -
FE252_RS16475 3047553..3048290 - 738 WP_000283664.1 zinc-binding phosphatase -
FE252_RS16480 3048345..3049283 - 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
FE252_RS16490 3049769..3050596 - 828 WP_001304477.1 DUF4942 domain-containing protein -
FE252_RS16495 3050681..3050878 - 198 WP_000772027.1 DUF957 domain-containing protein -
FE252_RS16500 3050898..3051386 - 489 WP_001054232.1 hypothetical protein -
FE252_RS16505 3051383..3051763 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
FE252_RS16510 3051810..3052184 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FE252_RS16515 3052234..3052878 - 645 WP_000086763.1 hypothetical protein -
FE252_RS16520 3052897..3053118 - 222 WP_000692315.1 DUF987 domain-containing protein -
FE252_RS16525 3053181..3053657 - 477 WP_001186170.1 RadC family protein -
FE252_RS16530 3053673..3054146 - 474 WP_000855076.1 antirestriction protein -
FE252_RS16535 3054409..3055230 - 822 WP_001234710.1 DUF945 domain-containing protein -
FE252_RS27340 3055311..3055522 + 212 Protein_2888 hypothetical protein -
FE252_RS16545 3055641..3056096 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T125855 WP_000854739.1 NZ_CP040456:c3051763-3051383 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T125855 NZ_CP040456:c3051763-3051383 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT125855 WP_001285482.1 NZ_CP040456:c3052184-3051810 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT125855 NZ_CP040456:c3052184-3051810 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References