Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2007818..2008652 Replicon chromosome
Accession NZ_CP040456
Organism Escherichia coli strain UPEC132

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2T3TJB4
Locus tag FE252_RS11190 Protein ID WP_000854811.1
Coordinates 2007818..2008195 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2T3TJJ3
Locus tag FE252_RS11195 Protein ID WP_001285590.1
Coordinates 2008284..2008652 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE252_RS11150 2003204..2004370 + 1167 WP_000830157.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
FE252_RS11155 2004489..2004962 + 474 WP_001105395.1 DNA gyrase inhibitor SbmC -
FE252_RS11160 2005161..2006219 + 1059 WP_001200890.1 FUSC family protein -
FE252_RS11165 2006391..2006720 + 330 WP_000450409.1 DUF496 family protein -
FE252_RS11170 2006821..2007003 - 183 WP_001016346.1 hypothetical protein -
FE252_RS11175 2007057..2007203 + 147 Protein_1862 transposase domain-containing protein -
FE252_RS11180 2007492..2007605 - 114 WP_001161660.1 DUF957 domain-containing protein -
FE252_RS11185 2007618..2007821 - 204 WP_000777677.1 hypothetical protein -
FE252_RS11190 2007818..2008195 - 378 WP_000854811.1 type IV toxin-antitoxin system toxin CbtA Toxin
FE252_RS11195 2008284..2008652 - 369 WP_001285590.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FE252_RS11200 2008726..2008947 - 222 WP_000692300.1 DUF987 domain-containing protein -
FE252_RS11205 2009016..2009492 - 477 WP_001186771.1 RadC family protein -
FE252_RS11210 2009508..2009993 - 486 WP_000849565.1 antirestriction protein -
FE252_RS11215 2010048..2010869 - 822 WP_145747956.1 DUF945 domain-containing protein -
FE252_RS11225 2011090..2011500 - 411 WP_000846713.1 hypothetical protein -
FE252_RS11230 2011516..2012199 - 684 WP_000775499.1 hypothetical protein -
FE252_RS11235 2012335..2013405 - 1071 WP_000102629.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gtrB / gtrA 1993050..2014307 21257


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14041.14 Da        Isoelectric Point: 7.8839

>T125844 WP_000854811.1 NZ_CP040456:c2008195-2007818 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

>T125844 NZ_CP040456:c2008195-2007818 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTTCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAATATTATCCTGGGTAAGCACCCGGAGGTGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13608.50 Da        Isoelectric Point: 6.6242

>AT125844 WP_001285590.1 NZ_CP040456:c2008652-2008284 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT125844 NZ_CP040456:c2008652-2008284 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
ACAGCAATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3TJB4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3TJJ3

References